What the FDA labels say about taking them together
Acetaminophen and busulfan
Busulfan's FDA label of June 27, 2024 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name busulfan. The busulfan label: “DRUG INTERACTIONS Drugs that Decrease Busulfan Clearance: Metronidazole, itraconazole, iron chelating agents, acetaminophen. Drugs that Increase Busulfan Clearance:”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the busulfan FDA label on DailyMed (effective June 27, 2024, Eugia US LLC).
What does the acetaminophen label say about busulfan?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name busulfan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the busulfan label say about acetaminophen?
Busulfan label, drug interactionsDRUG INTERACTIONS Drugs that Decrease Busulfan Clearance: Metronidazole, itraconazole, iron chelating agents, acetaminophen. ( 7.1 ) Drugs that Increase Busulfan Clearance:
Source: FDA drug label (Busulfan), Eugia US LLC, effective June 27, 2024 (SPL set 06883ac0-4b2a-4f26-89bf-512d37b9ba7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Busulfan | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once