What the FDA labels say about taking them together
Acalabrutinib and rifampin
Acalabrutinib's FDA label (Calquence) of February 19, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name acalabrutinib. The acalabrutinib label: “Co-administration of CALQUENCE with a strong CYP3A inducer (rifampin) decreased acalabrutinib plasma concentrations.”
Check it at the source: the acalabrutinib FDA label on DailyMed (effective February 19, 2026, AstraZeneca Pharmaceuticals LP); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the acalabrutinib label say about rifampin?
Calquence label (AstraZeneca Pharmaceuticals LP, February 19, 2026), drug interactionsCo-administration of CALQUENCE with a strong CYP3A inducer (rifampin) decreased acalabrutinib plasma concentrations [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Calquence, NDA210259), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set dd4835ef-e1bc-4997-a399-1ffa2556fbfe), via openFDA
Source: FDA drug label (CALQUENCE), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set b1409184-3267-4d8c-8f17-4e01f69828b1), via openFDA; the full label on DailyMed
What does the rifampin label say about acalabrutinib?
Rifampin's label (effective February 11, 2026) does not name acalabrutinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acalabrutinib | Rifampin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once