What the FDA labels say about taking them together
Acalabrutinib and obinutuzumab
Acalabrutinib's FDA label of February 19, 2026 names obinutuzumab in its warnings and precautions section; the obinutuzumab label PlainMeds reads does not name acalabrutinib. The acalabrutinib label: “… (9%) in 1,758 patients treated with CALQUENCE alone and in combination with obinutuzumab or venetoclax;”
Check it at the source: the acalabrutinib FDA label on DailyMed (effective February 19, 2026, AstraZeneca Pharmaceuticals LP); the obinutuzumab FDA label on DailyMed (effective December 19, 2025, Genentech, Inc.).
What does the acalabrutinib label say about obinutuzumab?
Acalabrutinib label, warnings and precautionsGrade 3 or 4 cytopenias included absolute neutrophil count decreased (28%), absolute lymphocyte count decreased (10%), hemoglobin decreased (9%), and platelets decreased (9%) in 1,758 patients treated with CALQUENCE alone and in combination with obinutuzumab or venetoclax;
Source: FDA drug label (CALQUENCE), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set b1409184-3267-4d8c-8f17-4e01f69828b1), via openFDA; the full label on DailyMed
What does the obinutuzumab label say about acalabrutinib?
Obinutuzumab's label (effective December 19, 2025) does not name acalabrutinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Gazyva), Genentech, Inc., effective December 19, 2025 (SPL set df12ceb2-5b4b-4ab5-a317-2a36bf2a3cda), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acalabrutinib | Obinutuzumab | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once