What the FDA labels say about taking them together
Acalabrutinib and itraconazole
Acalabrutinib's FDA label (Calquence) of February 19, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name acalabrutinib. The acalabrutinib label: “Co-administration of CALQUENCE with a strong CYP3A inhibitor (itraconazole) increased acalabrutinib plasma concentrations.”
Check it at the source: the acalabrutinib FDA label on DailyMed (effective February 19, 2026, AstraZeneca Pharmaceuticals LP); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the acalabrutinib label say about itraconazole?
Calquence label (AstraZeneca Pharmaceuticals LP, February 19, 2026), drug interactionsCo-administration of CALQUENCE with a strong CYP3A inhibitor (itraconazole) increased acalabrutinib plasma concentrations [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Calquence, NDA210259), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set dd4835ef-e1bc-4997-a399-1ffa2556fbfe), via openFDA
Source: FDA drug label (CALQUENCE), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set b1409184-3267-4d8c-8f17-4e01f69828b1), via openFDA; the full label on DailyMed
What does the itraconazole label say about acalabrutinib?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name acalabrutinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acalabrutinib | Itraconazole | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once