What the FDA labels say about taking them together
Acalabrutinib and famotidine
Acalabrutinib's FDA label (Calquence) of February 19, 2026 names famotidine in its drug interactions section; the famotidine labels PlainMeds reads (2) do not name acalabrutinib.
Check it at the source: the acalabrutinib FDA label on DailyMed (effective February 19, 2026, AstraZeneca Pharmaceuticals LP); the famotidine FDA label on DailyMed (effective February 6, 2026, Kenvue Brands LLC).
What does the acalabrutinib label say about famotidine?
Calquence label (AstraZeneca Pharmaceuticals LP, February 19, 2026), drug interactionsIf treatment with a gastric acid reducing agent is required, consider using a H2‑receptor antagonist (e.g., ranitidine or famotidine) or an antacid (e.g., calcium carbonate).
Source: FDA drug label (Calquence, NDA210259), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set dd4835ef-e1bc-4997-a399-1ffa2556fbfe), via openFDA
Source: FDA drug label (CALQUENCE), AstraZeneca Pharmaceuticals LP, effective February 19, 2026 (SPL set b1409184-3267-4d8c-8f17-4e01f69828b1), via openFDA; the full label on DailyMed
What does the famotidine label say about acalabrutinib?
Famotidine's label (effective February 6, 2026) and its 1 other brand-application label do not name acalabrutinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Pepcid AC Original Strength), Kenvue Brands LLC, effective February 6, 2026 (SPL set 54f4086f-e443-4e7e-8c7e-94e152e1c256), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acalabrutinib | Famotidine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0289 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once