What the FDA labels say about taking them together
Abrocitinib and fluconazole
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names abrocitinib in its drug interactions section; the abrocitinib label PlainMeds reads does not name fluconazole. The fluconazole label: “Abrocitinib Drug interaction studies indicate that when coadministered with fluconazole, the systemic exposure of abrocitinib and its active metabolites increased. Avoid concomitant use of abrocitinib with fluconazole.”
Check it at the source: the abrocitinib FDA label on DailyMed (effective September 9, 2026, Pfizer Laboratories Div Pfizer Inc); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the abrocitinib label say about fluconazole?
Abrocitinib's label (effective September 9, 2026) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cibinqo), Pfizer Laboratories Div Pfizer Inc, effective September 9, 2026 (SPL set 3f6d6fcd-e9f9-42c8-bfa2-bb2cfc9ed258), via openFDA; the full label on DailyMed
What does the fluconazole label say about abrocitinib?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsAbrocitinib Drug interaction studies indicate that when coadministered with fluconazole (strong inhibitor of CYP2C19; moderate inhibitor of CYP2C9 and CYP3A4), the systemic exposure of abrocitinib and its active metabolites increased. (See CLINICAL PHARMACOLOGY . ) Avoid concomitant use of abrocitinib with fluconazole.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abrocitinib | Fluconazole | |
|---|---|---|
| Labeled for | Eczema (atopic dermatitis) | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $197.09 per tablet 100 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once