What the FDA labels say about taking them together
Abemaciclib and loperamide
Abemaciclib's FDA label of July 13, 2026 names loperamide in its warnings and precautions section; the loperamide label PlainMeds reads does not name abemaciclib. The abemaciclib label: “Instruct patients to start antidiarrheal therapy such as loperamide at the first sign of loose stools, increase oral fluids, and notify their healthcare provider for further instructions and appropriate follow up.”
Check it at the source: the abemaciclib FDA label on DailyMed (effective July 13, 2026, Eli Lilly and Company); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).
What does the abemaciclib label say about loperamide?
Abemaciclib label, warnings and precautionsInstruct patients to start antidiarrheal therapy such as loperamide at the first sign of loose stools, increase oral fluids, and notify their healthcare provider for further instructions and appropriate follow up [see Patient Counseling Information ( 17 )].
Source: FDA drug label (Verzenio), Eli Lilly and Company, effective July 13, 2026 (SPL set be4bc0de-0fdc-4d46-8d25-be43c79e6a06), via openFDA; the full label on DailyMed
What does the loperamide label say about abemaciclib?
Loperamide's label (effective June 3, 2026) does not name abemaciclib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abemaciclib | Loperamide | |
|---|---|---|
| Labeled for | Breast cancer | Diarrhea |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0549 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once