What the FDA labels say about taking them together
Abatacept and nicotine
Abatacept's FDA label of November 13, 2025 names nicotine in its drug interactions section; the nicotine labels PlainMeds reads (2) do not name abatacept. The abatacept label: “… that do not react with maltose, such as those based on glucose dehydrogenase nicotine adenine dinucleotide (GDH-NAD), glucose oxidase, or glucose hexokinase test methods.”
Check it at the source: the abatacept FDA label on DailyMed (effective November 13, 2025, E.R. Squibb & Sons, L.L.C.); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the abatacept label say about nicotine?
Abatacept label, drug interactionsWhen receiving intravenous ORENCIA, patients that require blood glucose monitoring should be advised to consider methods that do not react with maltose, such as those based on glucose dehydrogenase nicotine adenine dinucleotide (GDH-NAD), glucose oxidase, or glucose hexokinase test methods.
Source: FDA drug label (ORENCIA), E.R. Squibb & Sons, L.L.C., effective November 13, 2025 (SPL set 0836c6ac-ee37-5640-2fed-a3185a0b16eb), via openFDA; the full label on DailyMed
What does the nicotine label say about abatacept?
Nicotine's label (effective July 25, 2024) and its 1 other brand-application label do not name abatacept in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abatacept | Nicotine | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | Quitting smoking |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1,469.23 per mL 125 mg/mL syringe | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once