What the FDA labels say about taking them together
Abatacept and anakinra
Abatacept's FDA label of November 13, 2025 names anakinra in its drug interactions section; the anakinra label PlainMeds reads does not name abatacept. The abatacept label: “There is insufficient experience to assess the safety and efficacy of ORENCIA administered concurrently with other biologic RA therapy, such as anakinra, or other biologic PsA therapy, and JAK inhibitors and therefore …”
Check it at the source: the abatacept FDA label on DailyMed (effective November 13, 2025, E.R. Squibb & Sons, L.L.C.); the anakinra FDA label on DailyMed (effective April 3, 2026, Swedish Orphan Biovitrum AB (publ)).
What does the abatacept label say about anakinra?
Abatacept label, drug interactionsThere is insufficient experience to assess the safety and efficacy of ORENCIA administered concurrently with other biologic RA therapy, such as anakinra, or other biologic PsA therapy, and JAK inhibitors and therefore such use is not recommended. [see Warnings and Precautions (5.1) ].
Source: FDA drug label (ORENCIA), E.R. Squibb & Sons, L.L.C., effective November 13, 2025 (SPL set 0836c6ac-ee37-5640-2fed-a3185a0b16eb), via openFDA; the full label on DailyMed
What does the anakinra label say about abatacept?
Anakinra's label (effective April 3, 2026) does not name abatacept in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Kineret), Swedish Orphan Biovitrum AB (publ), effective April 3, 2026 (SPL set d9d74915-6606-4570-9c52-c4001d3177de), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abatacept | Anakinra | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1,469.23 per mL 125 mg/mL syringe | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once