What the FDA labels say about taking them together
Abacavir/lamivudine/zidovudine and riociguat
Abacavir/lamivudine/zidovudine's FDA label of October 31, 2023 names riociguat in its drug interactions section; the riociguat label PlainMeds reads does not name abacavir/lamivudine/zidovudine. The abacavir/lamivudine/zidovudine label: “The riociguat dose may need to be reduced. Sorbitol: Coadministration of lamivudine and sorbitol may decrease lamivudine concentrations; when possible, avoid chronic coadministration. Agents antagonistic with zidovudine:”
Check it at the source: the abacavir/lamivudine/zidovudine FDA label on DailyMed (effective October 31, 2023, Lupin Pharmaceuticals, Inc.); the riociguat FDA label on DailyMed (effective August 13, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the abacavir/lamivudine/zidovudine label say about riociguat?
Abacavir/lamivudine/zidovudine label, drug interactionsThe riociguat dose may need to be reduced. ( 7.1 ) Sorbitol: Coadministration of lamivudine and sorbitol may decrease lamivudine concentrations; when possible, avoid chronic coadministration. ( 7.2 ) Agents antagonistic with zidovudine:
Source: FDA drug label (ABACAVIR, LAMIVUDINE AND ZIDOVUDINE), Lupin Pharmaceuticals, Inc., effective October 31, 2023 (SPL set f5f7c0d9-a247-4308-8269-32accc490ea6), via openFDA; the full label on DailyMed
What does the riociguat label say about abacavir/lamivudine/zidovudine?
Riociguat's label (effective August 13, 2026) does not name abacavir/lamivudine/zidovudine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Adempas), Bayer HealthCare Pharmaceuticals Inc., effective August 13, 2026 (SPL set 7b57509a-3d5d-41d4-8fed-1471e26372a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abacavir/lamivudine/zidovudine | Riociguat | |
|---|---|---|
| Labeled for | HIV | Pulmonary arterial hypertension |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once