Prescription medicine
Silver sulfadiazine Brand names: Ssd, Silvadene, Thermazene
Silver sulfadiazine (Ssd) is a prescription medicine with an FDA approval on record since 1973. No generic is listed; pharmacies paid $0.260 per gram (Silver sulfadiazine 1% cream) in the October 7, 2026 NADAC survey.
- No generic listed
Check it at the source: the silver sulfadiazine FDA label on DailyMed (effective April 24, 2019, Dr Reddys Laboratories Inc); the NDA 17381 record on Drugs@FDA; every silver sulfadiazine label on DailyMed.
Highlights of the record
FDA label of April 24, 2019; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageSilver Sulfadiazine Cream is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
Forms and strengths
- 10 mg/g
- 10 g/1000g
Cream.
On the market
- Earliest approval on file
- November 26, 1973 Silvadene, King Pharms Llc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 14 of which 0 under generic applications, 13 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.260 per gram Silver sulfadiazine 1% cream
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 2,276 through July 30, 2026
What is silver sulfadiazine used for?
From the label: indications and usageSilver Sulfadiazine Cream is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
FDA pharmacologic class: Sulfonamide Antibacterial.
Source: FDA drug label (SSD Cream), Dr Reddys Laboratories Inc, effective April 24, 2019 (SPL set 30d6dc33-e457-466b-9159-d8e7cd791820), via openFDA; the full label on DailyMed
Is there a generic for silver sulfadiazine (Ssd)?
No generic silver sulfadiazine is approved (Drugs@FDA, October 8, 2026).
- 1973 earliest approval on file
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for silver sulfadiazine (Ssd)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.260 per gram (Silver sulfadiazine 1% cream), up 29% from $0.202 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Silver sulfadiazine 1% cream (generic)
- Silvadene 1% cream (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Silver sulfadiazine 1% cream | Generic | $0.260 per gram | n/a | +29% |
| Ssd 1% cream | Generic | $0.260 per gram | n/a | +28% |
| Silvadene 1% cream | Brand | $0.252 per gram | n/a | +2% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for silver sulfadiazine?
The FDA Adverse Event Reporting System holds 2,276 reports that list silver sulfadiazine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 291 are coded as a death and 784 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other sulfonamide antibacterials
- the pharmacologic class, with prices and generics
- Silver sulfadiazine side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other