Over-the-counter medication · Prenatal Vitamin
prenatal multivitamin
Also sold as Prenatal Plus. Prenatal Plus helps prevent neural tube defects in babies.
Data updated 2026-05-15
- 23
- InteractionsSeveral interactions
- $0.12
- Generic price (NADAC)
prenatal multivitamin (Prenatal Plus) is an over-the-counter Prenatal Vitamin. Prenatal Plus helps prevent neural tube defects in babies.
Prenatal Plus is a prescription multivitamin with omega-3 and iron. It helps improve nutrition before, during, and after pregnancy.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.12/unit
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Prenatal Plus helps prevent neural tube defects in babies.
Common side effects
Allergic reactions, Mild diarrhea, Itching
Key warnings
Accidental overdose of iron can cause fatal poisoning in children under 6.
The sections below are summarized in plain English from prenatal multivitamin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
This medicine contains L-methylfolate, which helps your body make important substances. It also contains omega-3 fatty acids and iron. These nutrients are important for a healthy pregnancy and baby development.
How to Take It
Take one white vitamin tablet, two red omega-3 softgels, and three white mineral capsules each day. You can take them before, during, or after pregnancy. Take them as your doctor tells you to.
This is a plain-language summary of prenatal multivitamin's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
This medicine is designed to be taken during pregnancy and while breastfeeding. Talk to your doctor if you have any concerns.
This is a plain-language summary of prenatal multivitamin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of prenatal multivitamin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store in a dry place at 71°F or below, away from light and moisture.
Serious Warnings
Accidental overdose of iron can cause fatal poisoning in children under 6. Keep this medicine out of reach of children. If a child overdoses, call a doctor or Poison Control Center right away.
Known Drug Interactions
• L-dopa, triamterene, colchicine, and trimethoprim may decrease plasma folate levels. Caution should be exercised with the concomitant use of folinic acid and trimethoprim- sulfamethoxazole for the acute treatment of Pneumocystis carinii pneumonia in patients with HIV infection as it is associated with increased rates of treatment failure and mortality in a placebo-controlled study.
Mechanism: Trimethoprim can lower the amount of folate, an important B-vitamin, in your blood. This can make the folate in your prenatal vitamin less effective.
What to do: Your doctor should use caution when prescribing these together and may need to monitor your vitamin levels.
Drugs which may interact with folate include: • Antiepileptic drugs (AED): The AED class including, but not limited to, phenytoin, carbamazepine, primidone, valproic acid, fosphenytoin, valproate, phenobarbital and lamotrigine have been shown to impair folate absorption and increase the metabolism of circulating folate. • Additionally, concurrent use of folic acid has been associated with enhanced phenytoin metabolism, lowering the level of the AED in the blood and allowing breakthrough seizures to occur. Caution should be used when prescribing this product among patients who are receiving...
Mechanism: The folic acid in the vitamin speeds up how fast your body breaks down the seizure medicine. This can lower the amount of medicine in your blood and make it less effective at preventing seizures.
What to do: Your doctor may need to check your blood levels and adjust your seizure medicine dose. Do not start or stop vitamins without talking to your healthcare provider first.
Metformin treatment in patients with type 2 diabetes decreases serum folate. Drugs which may interact with vitamin B 12 (Methylcobalamin): • Antibiotics, cholestyramine, colchicines, colestipol, metformin, para-aminosalicylic, and potassium chloride may decrease the absorption of vitamin B 12 .
Mechanism: Metformin can make it harder for your body to absorb vitamin B12 and can lower the amount of folate in your blood. This may reduce the benefits of the vitamins in your supplement.
What to do: Your doctor may need to monitor your vitamin levels with blood tests. You should continue taking your prenatal vitamins to help maintain healthy nutrient levels.
• Fluoxetine: Fluoxetine exerts a noncompetitive inhibition of the 5-methyltetrahydrofolate active transport in the intestine.
Mechanism: Fluoxetine can block the system that moves folate from your intestines into your body. This means you might not get the full amount of folate from your multivitamin.
What to do: Your doctor may monitor your folate levels while you are taking these together. Make sure to take your vitamins daily as directed by your healthcare provider.
• NSAIDs include ibuprofen, naproxen, indomethacin and sulindac.
Mechanism: Ibuprofen is a type of NSAID that can interfere with how your body absorbs or uses certain vitamins in your prenatal supplement.
What to do: Talk to your doctor about whether you should take these medications at different times of the day.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
What if I have a family history of bipolar disorder?
Can this medicine interfere with my seizure medication?
I am undergoing cancer treatment, can I take this?
What if I have anemia?
Can this medicine cause bleeding problems?
What should I tell my doctor before taking this?
What if I am allergic to shellfish?
Who should not take this medicine?
What if I experience side effects?
What does this medicine contain?
What are the common side effects of prenatal multivitamin?
Does prenatal multivitamin interact with other medications?
What drug class is prenatal multivitamin?
Is prenatal multivitamin safe during pregnancy?
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What the FDA Data Shows for prenatal multivitamin
The FDA label for prenatal multivitamin (sold under brand names such as Prenatal Plus) classifies it as an over-the-counter product in the Prenatal Vitamin class. Prenatal Plus helps prevent neural tube defects in babies. Official labeling lists 11 commonly reported side effects, including Allergic reactions, Mild diarrhea, Itching.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 23 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.12.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: March 10, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages