Prescription medicine
Penicillin g benzathine and penicillin g procaine Brand names: Bicillin; first approved as Bicillin C-R
Penicillin g benzathine and penicillin g procaine (Bicillin) is a prescription medicine with an FDA approval on record since 1953. No generic is listed in FDA's NDC Directory.
- No generic listed
- Boxed warning
Check it at the source: the penicillin g benzathine and penicillin g procaine FDA label on DailyMed (effective July 21, 2026, Pfizer Laboratories Div Pfizer Inc); the NDA 50138 record on Drugs@FDA; every penicillin g benzathine and penicillin g procaine label on DailyMed.
Highlights of the record
FDA label of July 21, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH..
Prior to administration of this drug, carefully read the WARNINGS , ADVERSE REACTIONS , and DOSAGE AND ADMINISTRATION sections of the labeling.
Used for
From the label: indications and usageTo reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R and other antibacterial drugs, Bicillin C-R should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Forms and strengths
- 2ml / 2ml
Injection (suspension).
On the market
- Earliest approval on file
- May 18, 1953 Bicillin C-R, King Pharms Llc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 81 through July 30, 2026
What is penicillin g benzathine and penicillin g procaine used for?
From the label: indications and usageTo reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R and other antibacterial drugs, Bicillin C-R should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. […]
FDA pharmacologic class: Penicillin-class Antibacterial.
Source: FDA drug label (BICILLIN CR), NDA050138 (King Pharms Llc), as published by Pfizer Laboratories Div Pfizer Inc, effective July 21, 2026 (SPL set b5640fc6-76d8-428d-80e6-760d769af8bb), via openFDA; the full label on DailyMed
Is there a generic for penicillin g benzathine and penicillin g procaine (Bicillin)?
No generic penicillin g benzathine and penicillin g procaine is approved (Drugs@FDA, October 8, 2026).
- 1953 earliest approval on file
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What does the penicillin g benzathine and penicillin g procaine label say about other medicines?
The penicillin g benzathine and penicillin g procaine label names 29 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Acetaminophen | drug interactions | Class: Other drugs; Examples: acetaminophen, metoclopramide, quinine, sulfasalazine |
| Benzocaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Bupivacaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Chloroquine | drug interactions | Class: Antimalarials; Examples: chloroquine, primaquine |
| Cyclophosphamide | drug interactions | Class: Antineoplastic agents; Examples: cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase |
| Dapsone | drug interactions | Class: Antibiotics; Examples: dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides |
| Epinephrine | warnings | SERIOUS ANAPHYLACTIC REACTIONS REQUIRE IMMEDIATE EMERGENCY TREATMENT WITH EPINEPHRINE. |
| Flutamide | drug interactions | Class: Antineoplastic agents; Examples: cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase |
| Hydroxyurea | drug interactions | Class: Antineoplastic agents; Examples: cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase |
| Ifosfamide | drug interactions | Class: Antineoplastic agents; Examples: cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase |
| Lidocaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Mepivacaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Methylene blue | warnings | A more severe clinical presentation may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. |
| Metoclopramide | drug interactions | Class: Other drugs; Examples: acetaminophen, metoclopramide, quinine, sulfasalazine |
Every other medicine the penicillin g benzathine and penicillin g procaine label names
| Medicine named | Section | What the label says |
|---|---|---|
| Nitric oxide | drug interactions | Class: Nitrates/Nitrites; Examples: nitroglycerin, nitroprusside, nitric oxide, nitrous oxide |
| Nitrofurantoin | drug interactions | Class: Antibiotics; Examples: dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides |
| Nitroglycerin | drug interactions | Class: Nitrates/Nitrites; Examples: nitroglycerin, nitroprusside, nitric oxide, nitrous oxide |
| Nitrous oxide | drug interactions | Class: Nitrates/Nitrites; Examples: nitroglycerin, nitroprusside, nitric oxide, nitrous oxide |
| Penicillin g | warnings | The combination of penicillin G benzathine and penicillin G procaine should only be prescribed for the indications listed in this insert. |
| Phenobarbital | drug interactions | Class: Anticonvulsants; Examples: phenobarbital, sodium valproate |
| Prilocaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Primaquine | drug interactions | Class: Antimalarials; Examples: chloroquine, primaquine |
| Probenecid | drug interactions | Concurrent administration of penicillin and probenecid increases and prolongs serum penicillin levels by decreasing the apparent volume of distribution and slowing the rate of excretion by … |
| Quinine | drug interactions | Class: Other drugs; Examples: acetaminophen, metoclopramide, quinine, sulfasalazine |
| Rasburicase | drug interactions | Class: Antineoplastic agents; Examples: cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase |
| Ropivacaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Sulfasalazine | drug interactions | Class: Other drugs; Examples: acetaminophen, metoclopramide, quinine, sulfasalazine |
| Tetracaine | drug interactions | Class: Local anesthetics; Examples: articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine |
| Tetracycline | drug interactions | Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. |
Check penicillin g benzathine and penicillin g procaine against other medicines
Source: FDA drug label (BICILLIN CR), NDA050138 (King Pharms Llc), as published by Pfizer Laboratories Div Pfizer Inc, effective July 21, 2026 (SPL set b5640fc6-76d8-428d-80e6-760d769af8bb), via openFDA; the full label on DailyMed
What do FAERS reports show for penicillin g benzathine and penicillin g procaine?
The FDA Adverse Event Reporting System holds 81 reports that list penicillin g benzathine and penicillin g procaine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 8 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other penicillins
- the pharmacologic class, with prices and generics
- Penicillin g benzathine and penicillin g procaine side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other