netarsudil
Brand names: Rhopressa
Rhopressa is an eye drop medicine. It helps lower pressure in the eye.
Drug Pricing (NADAC)
Brand Price
$124.50/unit
Generic Available
No
ALCON LABS INC
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Rhopressa is used to lower high pressure inside the eye.
Common side effects
Eye redness (53%), Corneal verticillata (20%), Pain where the drop is applied (20%)
Key warnings
Some patients have developed swelling of the cornea while using Rhopressa.
How It Works
Rhopressa belongs to a class of drugs called Rho kinase inhibitors. It works by helping fluid drain better from the eye. This lowers the pressure inside the eye.
How to Take It
Use one drop of Rhopressa in the affected eye(s) once a day, in the evening. If you miss a dose, just continue with your next evening dose. Do not use it more than once a day. If you use other eye drops, wait at least 5 minutes before using Rhopressa.
Pregnancy & Breastfeeding
It is not known if Rhopressa will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Rhopressa passes into breast milk. Talk to your doctor about breastfeeding while using this medicine.
Missed Dose
If you miss a dose, continue with the next dose in the evening. Do not use a double dose to make up for a missed one.
Storage
Keep Rhopressa in the refrigerator until you open it. After opening, you can store it in the refrigerator or at room temperature for up to 6 weeks. If stored in the refrigerator after opening, it can be used until the expiration date on the bottle.
Side Effects (from patient reports)
Based on 1,272 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 1,797 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
1,797
Death-Related Reports
56
Hospitalization Reports
97
Top Indication
Glaucoma
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | CONJUNCTIVAL HYPERAEMIA | 244 |
| 2 | VISION BLURRED | 149 |
| 3 | OFF LABEL USE | 145 |
| 4 | EYE PAIN | 134 |
| 5 | OCULAR HYPERAEMIA | 133 |
| 6 | EYE IRRITATION | 109 |
| 7 | CORNEAL OEDEMA | 95 |
| 8 | INTRAOCULAR PRESSURE INCREASED | 88 |
| 9 | VISUAL ACUITY REDUCED | 88 |
| 10 | LACRIMATION INCREASED | 87 |
| 11 | PRODUCT DOSE OMISSION ISSUE | 70 |
| 12 | DRUG INEFFECTIVE | 67 |
| 13 | EYE PRURITUS | 64 |
| 14 | CORNEA VERTICILLATA | 59 |
| 15 | HEADACHE | 53 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Some patients have developed swelling of the cornea while using Rhopressa. Tell your doctor if you have eye pain or vision changes. Using multi-dose bottles of eye drops can sometimes cause bacterial infections of the cornea.
Common Questions
What if I wear contact lenses?
Can I use Rhopressa more than once a day?
What should I do if my eyes get irritated?
How long does Rhopressa take to work?
Is Rhopressa safe for children?
Can elderly patients use Rhopressa?
What is the strength of Rhopressa?
What if the bottle is left at room temperature during shipping?
What is corneal verticillata?
What if I use too much Rhopressa?
What are the common side effects of netarsudil?
What drug class is netarsudil?
Is netarsudil safe during pregnancy?
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What the FDA Data Shows for netarsudil
The FDA label for netarsudil (sold under brand names such as Rhopressa) classifies it as a prescription-only medication in the Rho Kinase Inhibitor (Ophthalmic) class. Rhopressa is used to lower high pressure inside the eye. Official labeling lists 4 commonly reported side effects, including Eye redness (53%), Corneal verticillata (20%), Pain where the drop is applied (20%).
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,272 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 20, 2026
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages