Prescription medication · Rho Kinase Inhibitor (Ophthalmic)
netarsudil
Also sold as Rhopressa. Rhopressa is used to lower high pressure inside the eye.
Data updated 2026-05-15
- 1,797
- FDA reportsRarely reported
- $124.50
- Brand price (NADAC)
netarsudil (Rhopressa) is a prescription Rho Kinase Inhibitor (Ophthalmic). Rhopressa is used to lower high pressure inside the eye.
Rhopressa is an eye drop medicine. It helps lower pressure in the eye.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$124.50/unit
Generic Available
No
ALCON LABS INC
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Rhopressa is used to lower high pressure inside the eye.
Common side effects
Eye redness (53%), Corneal verticillata (20%), Pain where the drop is applied (20%)
Key warnings
Some patients have developed swelling of the cornea while using Rhopressa.
The sections below are summarized in plain English from netarsudil's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Rhopressa belongs to a class of drugs called Rho kinase inhibitors. It works by helping fluid drain better from the eye. This lowers the pressure inside the eye.
How to Take It
Use one drop of Rhopressa in the affected eye(s) once a day, in the evening. If you miss a dose, just continue with your next evening dose. Do not use it more than once a day. If you use other eye drops, wait at least 5 minutes before using Rhopressa.
This is a plain-language summary of netarsudil's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
It is not known if Rhopressa will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Rhopressa passes into breast milk. Talk to your doctor about breastfeeding while using this medicine.
This is a plain-language summary of netarsudil's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, continue with the next dose in the evening. Do not use a double dose to make up for a missed one.
This is a plain-language summary of netarsudil's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Keep Rhopressa in the refrigerator until you open it. After opening, you can store it in the refrigerator or at room temperature for up to 6 weeks. If stored in the refrigerator after opening, it can be used until the expiration date on the bottle.
Side Effects (from patient reports)
Based on 1,797 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for netarsudil, by number of reports
- Eye redness
Eye redness
244 reports
- Blurred vision
Blurred vision
149 reports
- Eye pain
Eye pain
134 reports
- Eye redness
Eye redness
133 reports
- Eye irritation
Eye irritation
109 reports
- Swelling of the cornea 95
Swelling of the cornea
95 reports
- Increased pressure in the eye 88
Increased pressure in the eye
88 reports
- Reduced sharpness of vision 88
Reduced sharpness of vision
88 reports
- Increased tearing 87
Increased tearing
87 reports
- Eye itching 64
Eye itching
64 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for netarsudil each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where netarsudil sits
netarsudil has more FDA adverse-event reports than 11% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is netarsudil; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,797 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
1,797
Reports Mentioning Death
56
3.1% of reports — not proof of cause
Hospitalization Reports
97
Top Indication
Glaucoma
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | CONJUNCTIVAL HYPERAEMIA | 244 |
| 2 | VISION BLURRED | 149 |
| 4 | EYE PAIN | 134 |
| 5 | OCULAR HYPERAEMIA | 133 |
| 6 | EYE IRRITATION | 109 |
| 7 | CORNEAL OEDEMA | 95 |
| 8 | INTRAOCULAR PRESSURE INCREASED | 88 |
| 9 | VISUAL ACUITY REDUCED | 88 |
| 10 | LACRIMATION INCREASED | 87 |
| 13 | EYE PRURITUS | 64 |
| 14 | CORNEA VERTICILLATA | 59 |
| 15 | HEADACHE | 53 |
| 16 | DEATH | 49 |
| 17 | FATIGUE | 43 |
| 18 | VISUAL IMPAIRMENT | 42 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Some patients have developed swelling of the cornea while using Rhopressa. Tell your doctor if you have eye pain or vision changes. Using multi-dose bottles of eye drops can sometimes cause bacterial infections of the cornea.
Common Questions
What if I wear contact lenses?
Can I use Rhopressa more than once a day?
What should I do if my eyes get irritated?
How long does Rhopressa take to work?
Is Rhopressa safe for children?
Can elderly patients use Rhopressa?
What is the strength of Rhopressa?
What if the bottle is left at room temperature during shipping?
What is corneal verticillata?
What if I use too much Rhopressa?
What are the common side effects of netarsudil?
What drug class is netarsudil?
Is netarsudil safe during pregnancy?
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What the FDA Data Shows for netarsudil
The FDA label for netarsudil (sold under brand names such as Rhopressa) classifies it as a prescription-only medication in the Rho Kinase Inhibitor (Ophthalmic) class. Rhopressa is used to lower high pressure inside the eye. Official labeling lists 4 commonly reported side effects, including Eye redness (53%), Corneal verticillata (20%), Pain where the drop is applied (20%).
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,797 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 20, 2026
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages