acarbose vs linagliptin
Side-by-side comparison of acarbose and linagliptin Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Precose
Tradjenta
Acarbose is a medicine that helps lower blood sugar levels in people with type 2 diabetes. It works best when used with diet and exercise.
Jentadueto XR is a drug that combines linagliptin and metformin. It helps lower blood sugar in adults with type 2 diabetes, along with diet and exercise.
Acarbose is used to help control blood sugar in adults with type 2 diabetes. You should use it along with a healthy diet and regular exercise. This medicine helps to keep your blood sugar from getting too high after you eat.
Jentadueto XR is used to improve blood sugar control in adults with type 2 diabetes. It should be used in addition to diet and exercise. It is not for people with type 1 diabetes. It has not been studied in patients with a history of pancreatitis.
Acarbose slows down the digestion of carbohydrates (sugars and starches) in your body. It does this by blocking certain enzymes in your small intestine that break down carbs. This helps to prevent a sharp rise in blood sugar after meals.
This medicine contains two drugs. Linagliptin helps your body release more insulin after you eat. Metformin helps your body use insulin better and reduces sugar production in the liver.
- • Gas
- • Diarrhea
- • Abdominal pain
- • Runny nose or sore throat
- • Diarrhea
- Low blood sugar 269
- Feeling sick to your stomach 203
- High blood sugar 200
- Feeling lightheaded 160
- Loose, watery stools 147
- High blood sugar 1,326
- Diarrhea 1,196
- Nausea 1,138
- Tiredness 1,028
- Difficulty breathing 998
You should not take acarbose if you have diabetic ketoacidosis or cirrhosis. Also, do not take it if you have inflammatory bowel disease, colon ulcers, or any bowel obstruction. This medicine can cause liver problems in some people. Tell your doctor right away if you develop symptoms like yellowing of the skin or eyes.
Jentadueto XR can cause a serious side effect called lactic acidosis. This is a buildup of lactic acid in your blood. Get medical help right away if you have symptoms like weakness, muscle pain, trouble breathing, stomach pain, dizziness, or a slow or irregular heartbeat. Certain conditions increase your risk, such as kidney problems, drinking a lot of alcohol, or having surgery.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if acarbose will harm your unborn baby. Talk to your doctor if you are breastfeeding or plan to breastfeed. It is not known if acarbose passes into breast milk.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if Jentadueto XR will harm your unborn baby. Discuss the best way to control your blood sugar during pregnancy with your doctor.
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How to Read This acarbose vs linagliptin Comparison
acarbose is classified in the Alpha-Glucosidase Inhibitor drug class, while linagliptin sits within the DPP-4 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acarbose has 979 submissions while linagliptin has 5,686. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between acarbose and linagliptin — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.