insulin regular

7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN R Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN R is co-administered with these drugs.

Mechanism: Fluoxetine can increase the blood-sugar-lowering effect of insulin, which may cause your blood sugar to drop to an unsafe level.

What to do: Your doctor may need to change your insulin dose and you should check your blood sugar more often.

7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN R Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN R is co-administered with these drugs.

Mechanism: Pramlintide increases the risk of low blood sugar when used with insulin because both drugs work to lower glucose levels.

What to do: Your healthcare provider may need to adjust your insulin dose and you should monitor your blood sugar more closely.

7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN R Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN R is co-administered with these drugs.

Mechanism: Octreotide can lower blood sugar levels, which adds to the effect of insulin and increases the risk of a dangerous drop.

What to do: Your doctor may need to adjust your insulin dose and you should check your blood sugar levels more frequently.

Drugs that May Decrease the Blood Glucose Lowering Effect of HUMULIN R Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.

Mechanism: Albuterol can cause the body to produce more sugar or make it harder for insulin to lower it. This means your blood sugar might not drop as much as it usually does with insulin.

What to do: Monitor your blood sugar closely when starting or changing your dose of this medication. Your doctor may need to increase your insulin dose.

Drugs that May Increase or Decrease the Blood Glucose Lowering Effect of HUMULIN R Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs that May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when HUMULIN R is co-administered with these drugs. ( 7 ) Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Signs and symptoms of hypoglycemia may be reduced or absent.

Mechanism: This drug can change how your body responds to insulin and may also hide the warning signs of low blood sugar, like a fast heartbeat. This makes it harder to tell if your blood sugar has dropped too low.

What to do: You should check your blood sugar more frequently because you might not feel the usual symptoms of a low. Your doctor will help you adjust your insulin dose as needed.