Prescription medication · Beta-2 Agonist / Anticholinergic Combination

albuterol/ipratropium

Also sold as Combivent Respimat, DuoNeb. This medicine treats Chronic Obstructive Pulmonary Disease (COPD).

Data updated 2026-05-15

75,724
FDA reports
1
InteractionFew interactions
$117.27
Brand price (NADAC)

What the data shows

albuterol/ipratropium (Combivent Respimat) is a prescription Beta-2 Agonist / Anticholinergic Combination, with 75,724 FDA adverse-event reports on file, with 1 documented drug interaction.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

albuterol/ipratropium (Combivent Respimat) is a prescription Beta-2 Agonist / Anticholinergic Combination. This medicine treats Chronic Obstructive Pulmonary Disease (COPD).

Combivent Respimat is a combination medicine that helps open your airways. It contains two medicines: ipratropium and albuterol.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$117.27/unit

Generic Available

No

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

This medicine treats Chronic Obstructive Pulmonary Disease (COPD).

Common side effects

Upper respiratory infection, Runny nose and sore throat, Cough

Key warnings

Combivent Respimat can cause your breathing to get worse (paradoxical bronchospasm).

The sections below are summarized in plain English from albuterol/ipratropium's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Combivent Respimat contains two medicines that work in different ways. Albuterol relaxes the muscles in your airways, opening them up. Ipratropium helps to prevent the muscles around your airways from tightening.

Side Effects (from patient reports)

Based on 75,724 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for albuterol/ipratropium, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

Combivent Respimat can cause your breathing to get worse (paradoxical bronchospasm). If this happens, stop using it right away and get medical help. This medicine can also cause heart problems, eye problems, and trouble urinating. Tell your doctor if you have any of these conditions.

Known Drug Interactions

moderate albuterol

Avoid coadministration of COMBIVENT RESPIMAT and other sympathomimetic agents (7.2) Beta-blockers: Inhibit the effect of albuterol. (7.4) Monoamine oxidase inhibitors (MAOs) or tricyclic antidepressants: May potentiate effect of albuterol on the vascular system. 7.3 Beta-receptor Blocking Agents Beta-receptor blocking agents and albuterol inhibit the effect of each other.

Mechanism: Both of these products contain the same type of medicine. Taking them together can cause you to get too much of the drug, which can lead to a racing heart or jitters.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

What should I do if Combivent Respimat makes my breathing worse?
Stop using Combivent Respimat immediately and seek medical attention.
Can Combivent Respimat affect my heart?
Yes, it can cause cardiovascular effects. Use with caution if you have heart problems.
Is it safe to spray Combivent Respimat in my eyes?
No, avoid spraying it in your eyes. It can cause eye pain, blurred vision, and other problems.
Can Combivent Respimat cause urinary problems?
Yes, it can cause urinary retention. Use with caution if you have prostate or bladder problems.
What if I am allergic to Combivent Respimat?
You should not use Combivent Respimat if you are allergic to any of its ingredients or to atropine.
Can I use Combivent Respimat with other inhalers?
Talk to your doctor before using Combivent Respimat with other medicines, including other inhalers.
How do I know when my Combivent Respimat inhaler is empty?
The inhaler has a dose indicator. When the labeled number of puffs has been used, the inhaler will lock.
Can I use Combivent Respimat if I have diabetes?
Use Combivent Respimat with caution if you have diabetes.
How often should I clean my Combivent Respimat inhaler?
Follow the instructions in the patient information leaflet for cleaning your inhaler.
What do I do if Combivent Respimat doesn't seem to be working?
Talk to your doctor if your symptoms do not improve or if they get worse.
What are the common side effects of albuterol/ipratropium?
The registry lists Upper respiratory infection, Runny nose and sore throat, Cough, Bronchitis, Headache among the most-reported FAERS reaction terms for albuterol/ipratropium. The compiled record contains 75,724 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does albuterol/ipratropium interact with other medications?
The registry has 1 documented interaction rows for albuterol/ipratropium. Notable source-record pairings include albuterol. These rows are not a complete medication review.
What drug class is albuterol/ipratropium?
albuterol/ipratropium belongs to the Beta-2 Agonist / Anticholinergic Combination drug class. It requires a prescription (Rx). This medicine treats Chronic Obstructive Pulmonary Disease (COPD).
What pregnancy or breastfeeding source fields are listed for albuterol/ipratropium?
The FDA label for albuterol/ipratropium contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

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What the FDA Data Shows for albuterol/ipratropium

The FDA label for albuterol/ipratropium (sold under brand names such as Combivent Respimat, DuoNeb) classifies it as a prescription-only medication in the Beta-2 Agonist / Anticholinergic Combination class. This medicine treats Chronic Obstructive Pulmonary Disease (COPD). Official labeling lists 6 commonly reported side effects, including Upper respiratory infection, Runny nose and sore throat, Cough.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 75,724 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: December 1, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page