Prescription medicine

Colistin, hydrocortisone, neomycin and thonzonium Brand names: Cortisporin; first approved as Coly-Mycin S

Colistin, hydrocortisone, neomycin and thonzonium (Cortisporin) is a prescription medicine with an FDA approval on record since 1962. No generic is listed; pharmacies paid $21.98 per mL (Cortisporin-tc ear suspension) in the October 7, 2026 NADAC survey.

No generic listed

Check it at the source: the colistin, hydrocortisone, neomycin and thonzonium FDA label on DailyMed (effective August 1, 2024, Endo USA, Inc.); the NDA 50356 record on Drugs@FDA; every colistin, hydrocortisone, neomycin and thonzonium label on DailyMed.

Highlights of the record

FDA label of August 1, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026

Used for

From the label: indications and usage
Cortisporin ® TC Otic is indicated for the treatment of superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics;

Forms and strengths

3 mg/ml / 3.3 mg/ml / 0.5 mg/ml / 10 mg/ml

Suspension.

On the market

Earliest approval on file: May 17, 1962 Coly-Mycin S, Ph Health; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals: No generic approved
Labelers listed (NDC): 1 of which 0 under generic applications, 1 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC): $21.98 per mL Cortisporin-tc ear suspension
Shortage (FDA): No current entry
Recalls by its makers (FDA): No recall recorded
FAERS reports: 2 through July 30, 2026

What is colistin, hydrocortisone, neomycin and thonzonium used for?

From the label: indications and usage
Cortisporin ® TC Otic is indicated for the treatment of superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics; and for the treatment of infections of mastoidectomy and fenestration cavities, caused by organisms susceptible to the antibiotics.

Conditions named in the indications of colistin, hydrocortisone, neomycin and thonzonium's FDA labels, with every medicine labeled for each:

Bacterial infections

From other colistin, hydrocortisone, neomycin and thonzonium labels
Bacterial infections: INDICATIONS AND USAGE Cortisporin ® TC Otic is indicated for the treatment of superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics; …

FDA pharmacologic class: Aminoglycoside Antibacterial and Corticosteroid.

Source: FDA drug label (Cortisporin TC), NDA050356 (Ph Health), as published by Endo USA, Inc., effective August 1, 2024 (SPL set 9c6fc1c7-3350-42ae-b999-aca48e704bb1), via openFDA; the full label on DailyMed

Is there a generic for colistin, hydrocortisone, neomycin and thonzonium (Cortisporin)?

No generic colistin, hydrocortisone, neomycin and thonzonium is approved (Drugs@FDA, October 8, 2026).

1962 earliest approval on file

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What do pharmacies pay for colistin, hydrocortisone, neomycin and thonzonium (Cortisporin)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $21.98 per mL (Cortisporin-tc ear suspension), about the same as a year earlier. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

Cortisporin-tc ear suspension (brand)

$22.17

$21.96

April 2024October 2026

NADAC per unit, October 7, 2026
Strength and form	Brand or generic	Pharmacy cost	30 tablets, or one pen or vial	12-month change
Cortisporin-tc ear suspension	Brand	$21.98 per mL	n/a	-0.3%

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What do FAERS reports show for colistin, hydrocortisone, neomycin and thonzonium?

The FDA Adverse Event Reporting System holds 2 reports that list colistin, hydrocortisone, neomycin and thonzonium among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 2 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

The most reported reactions

Asthenia1
Central Nervous System Lymphoma1
Colitis1
Dehydration1
Diarrhoea1
Dizziness Postural1
Dysstasia1
Endophthalmitis1

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What else is labeled for the same conditions as colistin, hydrocortisone, neomycin and thonzonium?

2 other medicines are given the same way (auricular (otic)) and in the same FDA class as colistin, hydrocortisone, neomycin and thonzonium or labeled mainly for the same use (bacterial infections), the same class first. Bacterial infections lists all 51 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

Medicine	Shared indication	Generic labelers (auricular (otic))	Pharmacy cost	Shortage
Ciprofloxacin and dexamethasone	Bacterial infections	11 labelers	$7.12 per mL Ciproflox-dexameth ear suspension	No current entry
Ofloxacin	Bacterial infections	20 labelers	$1.04 per mL 0.3% ear drops	No current entry

Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)

What next?

Other aminoglycoside antibacterials: the pharmacologic class, with prices and generics
Colistin, hydrocortisone, neomycin and thonzonium side effects: the label's list beside FAERS reports
Check an interaction: what two or more labels say about each other