MID-VOLUME · HOSP-HEAVY
zonisamide Side Effects
zonisamide (also sold as Zonegran) sits MID-VOLUME #277 of 524 by FAERS report count. Lead signal: HOSP-HEAVY - 31.0% mention hospitalization (4,400 reports). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 14,210
- FAERS reports
FDA Adverse Event Reporting System extract for zonisamide. Stamp set WATCHLIST · DEATH-HEAVY · HOSP-HEAVY. How figures are compiled.
zonisamide: 31.0% mention hospitalization (4,400 reports). Death stamp DEATH-HEAVY; volume band MID-VOLUME #277 of 524 by FAERS report count.
Mid-book FAERS page for zonisamide (Zonegran) (14,210 reports). Signature HOSP-HEAVY. Dominant age band on file: 18-44. Educational reference only.
Counts from the openFDA FAERS extract (2004–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
SEIZURE leads 1,574 of 14,210 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (3,110 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (869 reports, 6.1%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 195 |
| COMPLETED SUICIDE | 59 |
| PNEUMONIA ASPIRATION | 55 |
| RESPIRATORY FAILURE | 41 |
| PNEUMONIA | 39 |
| TOXICITY TO VARIOUS AGENTS | 39 |
| SUDDEN UNEXPLAINED DEATH IN EPILEPSY | 38 |
| CARDIO-RESPIRATORY ARREST | 37 |
| CARDIAC ARREST | 34 |
| SEPTIC SHOCK | 33 |
| FOETAL EXPOSURE DURING PREGNANCY | 30 |
| SOMNOLENCE | 28 |
| STATUS EPILEPTICUS | 27 |
| FALL | 26 |
| SEIZURE | 25 |
| SEPSIS | 25 |
| ANXIETY | 23 |
| CONVULSION | 22 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (4,400, 31.0% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| SEIZURE | 449 |
| FALL | 249 |
| CONVULSION | 230 |
| SOMNOLENCE | 229 |
| VOMITING | 224 |
| PNEUMONIA | 219 |
| DRUG INTERACTION | 212 |
| PYREXIA | 201 |
| NAUSEA | 191 |
| DIZZINESS | 172 |
| FATIGUE | 171 |
| EPILEPSY | 154 |
| WEIGHT DECREASED | 154 |
| CONDITION AGGRAVATED | 152 |
| STATUS EPILEPTICUS | 146 |
| HEADACHE | 127 |
| ASTHENIA | 126 |
| DIARRHOEA | 120 |
How to read zonisamide FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 14,210 voluntary reports linked to zonisamide (Zonegran), 2004-2025. Death is listed on 869 (6.1%). Hospitalization appears on 4,400 (31.0%). Top co-reported indication: Product Used For Unknown Indication.
Mid-volume extract - treat DEATH-HEAVY · HOSP-HEAVY as signal-detection rates next to 31.0% mention hospitalization (4,400 reports).
Read with zonisamide
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 14,085 FAERS cases (Δ 125 lighter vs zonisamide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 14,399 FAERS cases (Δ 189 heavier vs zonisamide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 13,998 FAERS cases (Δ 212 lighter vs zonisamide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 14,664 FAERS cases (Δ 454 heavier vs zonisamide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 56.0 pp vs zonisamide's DEATH-HEAVY): CASELOAD · HOSP-MID.
zonisamide stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload WATCHLIST and the label guide.