MID-VOLUME · HOSP-HEAVY
metolazone Side Effects
metolazone (also sold as Zaroxolyn) sits MID-VOLUME #310 of 524 by FAERS report count. Lead signal: HOSP-HEAVY - 52.0% mention hospitalization (5,657 reports). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 10,872
- FAERS reports
FDA Adverse Event Reporting System extract for metolazone. Stamp set WATCHLIST · DEATH-HEAVY · HOSP-HEAVY. How figures are compiled.
metolazone: 52.0% mention hospitalization (5,657 reports). Death stamp DEATH-HEAVY; volume band MID-VOLUME #310 of 524 by FAERS report count.
Mid-book FAERS page for metolazone (Zaroxolyn) (10,872 reports). Signature HOSP-HEAVY. Dominant age band on file: 45-64. Educational reference only.
Counts from the openFDA FAERS extract (2003–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
DYSPNOEA leads 1,204 of 10,872 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (2,672 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (2,165 reports, 19.9%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 866 |
| DYSPNOEA | 273 |
| RENAL FAILURE | 228 |
| CARDIAC FAILURE CONGESTIVE | 227 |
| ACUTE KIDNEY INJURY | 201 |
| HYPOTENSION | 160 |
| CHRONIC KIDNEY DISEASE | 151 |
| CARDIAC FAILURE | 134 |
| NAUSEA | 134 |
| ASTHENIA | 127 |
| CARDIAC ARREST | 124 |
| PNEUMONIA | 123 |
| RESPIRATORY FAILURE | 118 |
| ATRIAL FIBRILLATION | 112 |
| OEDEMA PERIPHERAL | 112 |
| CONDITION AGGRAVATED | 111 |
| END STAGE RENAL DISEASE | 110 |
| DIARRHOEA | 106 |
| FATIGUE | 99 |
| SEPSIS | 98 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (5,657, 52.0% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| DYSPNOEA | 856 |
| CARDIAC FAILURE CONGESTIVE | 571 |
| ACUTE KIDNEY INJURY | 505 |
| PNEUMONIA | 444 |
| HYPOTENSION | 442 |
| NAUSEA | 436 |
| ASTHENIA | 413 |
| FALL | 398 |
| RENAL FAILURE | 391 |
| FATIGUE | 377 |
| OEDEMA PERIPHERAL | 374 |
| FLUID RETENTION | 370 |
| DIARRHOEA | 367 |
| DIZZINESS | 361 |
| ANAEMIA | 314 |
| DEHYDRATION | 307 |
| GASTROINTESTINAL HAEMORRHAGE | 296 |
| CARDIAC FAILURE | 292 |
| ATRIAL FIBRILLATION | 272 |
| VOMITING | 269 |
How to read metolazone FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 10,872 voluntary reports linked to metolazone (Zaroxolyn), 2003-2025. Death is listed on 2,165 (19.9%). Hospitalization appears on 5,657 (52.0%). Top co-reported indication: Product Used For Unknown Indication.
Mid-volume extract - treat DEATH-HEAVY · HOSP-HEAVY as signal-detection rates next to 52.0% mention hospitalization (5,657 reports).
Read with metolazone
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 11,019 FAERS cases (Δ 147 heavier vs metolazone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 11,035 FAERS cases (Δ 163 heavier vs metolazone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 10,687 FAERS cases (Δ 185 lighter vs metolazone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 11,087 FAERS cases (Δ 215 heavier vs metolazone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 42.2 pp vs metolazone's DEATH-HEAVY): CASELOAD · HOSP-MID.
metolazone stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload WATCHLIST and the label guide.