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fluvoxamine Side Effects

Also known as: Luvox

Analysis of 2,289 adverse event reports submitted to the FDA from 2004 to 2025.

Total Reports

2,289

Death-Related

254

11.1% of reports

Hospitalizations

876

38.3% of reports

Top Indication

Product Used For Unknown Indication

Most Reported Adverse Reactions

DRUG INTERACTION
215
DRUG INEFFECTIVE
135
NAUSEA
117
SOMNOLENCE
114
ANXIETY
103
SUICIDAL IDEATION
96
DEPRESSION
93
DIZZINESS
87
FATIGUE
86
HEADACHE
86
INSOMNIA
83
SEROTONIN SYNDROME
81
PYREXIA
80
CONDITION AGGRAVATED
79
SUICIDE ATTEMPT
77
TREMOR
77
OFF LABEL USE
75
VOMITING
75
TOXICITY TO VARIOUS AGENTS
70
COMPLETED SUICIDE
69

Who Reports Side Effects

Gender Distribution

Female 1,216 (56%)
Male 935 (43%)
Unknown 8

Age Distribution

0-17 160 (10%)
18-44 643 (40%)
45-64 444 (28%)
65-74 213 (13%)
75+ 134 (8%)

Reporting Trend by Year

2004 2025

Reactions in Death Reports

Top reactions reported in 254 reports where death was an outcome. These are voluntarily reported and do not establish causation.

Reaction Reports
COMPLETED SUICIDE 68
TOXICITY TO VARIOUS AGENTS 42
DEATH 31
DRUG INTERACTION 29
CARDIO-RESPIRATORY ARREST 24
INTENTIONAL OVERDOSE 19
OVERDOSE 19
DRUG TOXICITY 17
PULMONARY OEDEMA 14
CARDIAC ARREST 13
LOSS OF CONSCIOUSNESS 12
PNEUMONIA 11
METABOLIC ACIDOSIS 10
BRAIN OEDEMA 8
DEPRESSION 8
DRUG INEFFECTIVE 8
PULMONARY CONGESTION 8
SEPSIS 8
BLOOD PRESSURE DECREASED 7
COMA 7

Reactions in Hospitalization Reports

Top reactions in 876 reports where hospitalization was an outcome.

Reaction Reports
DRUG INTERACTION 118
DRUG INEFFECTIVE 59
SUICIDAL IDEATION 59
SUICIDE ATTEMPT 58
SEROTONIN SYNDROME 47
ANXIETY 45
PYREXIA 45
CONDITION AGGRAVATED 43
DEPRESSION 42
NAUSEA 42
SOMNOLENCE 40
DIZZINESS 36
HYPOTENSION 36
TREMOR 36
VOMITING 36
BLOOD CREATINE PHOSPHOKINASE INCREASED 35
FALL 34
ALANINE AMINOTRANSFERASE INCREASED 33
DIARRHOEA 31
INTENTIONAL OVERDOSE 30

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What the FAERS Data Reveals About fluvoxamine Side Effects

The FDA Adverse Event Reporting System (FAERS) contains 2,289 voluntary reports linked to fluvoxamine and its brand equivalents (Luvox), spanning 2004 through 2025. Of those, 254 (11.1%) listed death as an outcome and 876 (38.3%) involved hospitalization. The most common indication reported alongside adverse events was Product Used For Unknown Indication.

Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 56% were female and 43% male; age distribution skews toward 18-44, with 643 reports in that bracket. The single most reported reaction is drug interaction with 215 submissions, followed by drug ineffective and nausea.

FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice — speak with a licensed clinician about any side-effect concerns.