HIGH-VOLUME · FEMALE-LED
conjugated estrogens Side Effects
conjugated estrogens (also sold as Premarin) is HIGH-VOLUME in this FAERS book #126 of 524 by FAERS report count. Signature opener: FEMALE-LED - 100% of sex-coded reports are female (55,235 F / 187 M).
Data updated 2026-05-15
- 57,675
- FAERS reports
FAERS voluntary reports, 1996 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
conjugated estrogens reporting skew - 100% of sex-coded reports are female (55,235 F / 187 M). Volume band HIGH-VOLUME #126 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for conjugated estrogens (Premarin): 57,675 FAERS rows (1996-2025). Top named reactions: BREAST CANCER, BREAST CANCER FEMALE, NAUSEA. Outcome stamps DEATH-MARKED · HOSP-MID · FEMALE-LED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (1996–2025). Stamps CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
BREAST CANCER leads 9,623 of 57,675 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (100% of sex-coded rows)
Age peak 45-64 (15,624 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death appears on 1,777 reports (3.1% - MARKED). Reactions below co-occur in those rows only.
| Reaction | Reports |
|---|---|
| DEATH | 386 |
| BREAST CANCER METASTATIC | 206 |
| BREAST CANCER | 172 |
| BREAST CANCER FEMALE | 149 |
| PNEUMONIA | 105 |
| MYOCARDIAL INFARCTION | 104 |
| CARDIAC ARREST | 100 |
| CEREBROVASCULAR ACCIDENT | 82 |
| OVARIAN CANCER | 79 |
| RENAL FAILURE | 77 |
| CARDIAC FAILURE CONGESTIVE | 71 |
| DYSPNOEA | 71 |
| RESPIRATORY FAILURE | 68 |
| PAIN | 62 |
| ANXIETY | 61 |
| SEPSIS | 60 |
| HYPOTENSION | 59 |
| VOMITING | 57 |
| OVARIAN CANCER METASTATIC | 56 |
| NAUSEA | 55 |
Reactions in Hospitalization Reports
Hospitalization mid-share (9,226, 16.0%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| BREAST CANCER | 857 |
| NAUSEA | 781 |
| PAIN | 760 |
| DYSPNOEA | 759 |
| FALL | 722 |
| FATIGUE | 700 |
| CHEST PAIN | 622 |
| DEPRESSION | 617 |
| DIARRHOEA | 615 |
| HYPERTENSION | 612 |
| CEREBROVASCULAR ACCIDENT | 608 |
| DIZZINESS | 589 |
| HEADACHE | 587 |
| PNEUMONIA | 581 |
| ASTHENIA | 577 |
| ANXIETY | 569 |
| MYOCARDIAL INFARCTION | 529 |
| VOMITING | 510 |
| ARTHRALGIA | 466 |
How to read conjugated estrogens FAERS figures (CASELOAD · DEATH-MARKED · HOSP-MID)
FAERS holds 57,675 voluntary reports linked to conjugated estrogens (Premarin), 1996-2025. Death is listed on 1,777 (3.1%). Hospitalization appears on 9,226 (16.0%). Top co-reported indication: Hormone Replacement Therapy.
CASELOAD books overweight common drugs and loud reporting cultures; FEMALE-LED is the page opener, not a per-patient risk.
Read with conjugated estrogens
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-MARKED · HOSP-MID stamps.
ABS(total_reports) peer at 57,614 FAERS cases (Δ 61 lighter vs conjugated estrogens); DEATH-HEAVY · HOSP-MID · MALE-LED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 58,038 FAERS cases (Δ 363 heavier vs conjugated estrogens); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 58,495 FAERS cases (Δ 820 heavier vs conjugated estrogens); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 56,567 FAERS cases (Δ 1,108 lighter vs conjugated estrogens); DEATH-HEAVY · HOSP-MID · MALE-LED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 59.0 pp vs conjugated estrogens's DEATH-MARKED): CASELOAD · HOSP-MID.
conjugated estrogens sits in CASELOAD; high report volume tracks exposure and reporting culture more than per-patient risk. Methodology states the de-dup rules.