spironolactone vs valsartan
Side-by-side comparison of spironolactone and valsartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 Potassium-Sparing Diuretics As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium [see Warnings and Precautions (5.5)] .
Recommendation: Your doctor should monitor your blood potassium levels regularly while you are taking this combination.
Aldactone
Diovan
Spironolactone is a medicine that helps remove extra fluid from your body and lower blood pressure. It also helps your heart work better if you have heart failure.
Entresto is a medicine that combines two drugs to help adults and children with heart failure. It can lower the risk of death and hospitalization.
Spironolactone is used to treat heart failure by reducing fluid build-up and helping you live longer. It also treats high blood pressure, which can lower your chance of having a stroke or heart attack. This medicine can also manage fluid build-up caused by liver problems or a kidney problem called nephrotic syndrome. It can also treat a condition where your body makes too much of a hormone called aldosterone.
Entresto is used to treat heart failure in adults and children aged one year and older. It helps people whose hearts don't pump blood well enough. It can reduce hospital visits and the risk of death from heart problems.
Spironolactone belongs to a class of drugs called aldosterone antagonists. It works by blocking the effects of aldosterone, a hormone that causes your body to hold onto salt and water. By blocking aldosterone, spironolactone helps your body get rid of extra fluid and salt, which lowers blood pressure and reduces strain on the heart.
Entresto works by blocking two substances in your body that can worsen heart failure. One substance is neprilysin, and the other is angiotensin II. By blocking these, Entresto helps your heart pump blood more easily and reduces strain.
- • Breast enlargement in men
- • Dizziness
- • Headache
- • Low blood pressure
- • High potassium levels in your blood
- • Cough
- • Dizziness
- • Kidney problems
- Difficulty breathing 10,389
- Tiredness 8,179
- Feeling sick to your stomach 7,818
- Loose stools 7,416
- Sudden kidney damage 6,785
- Feeling tired 5,476
- Feeling lightheaded 5,251
- Difficulty breathing 5,251
- Feeling sick to your stomach 5,164
- Loose stools 4,581
Spironolactone can cause your potassium levels to get too high, which can be dangerous. Your doctor will check your potassium levels regularly, especially if you have kidney problems or are taking other medicines that can raise potassium. This medicine can also cause low blood pressure or make kidney problems worse. Tell your doctor if you have side effects.
Entresto can harm your unborn baby, even causing death. If you are pregnant or become pregnant, stop taking Entresto right away and tell your doctor.
Spironolactone may affect the sex organs of a baby boy if taken during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if spironolactone passes into breast milk, so talk to your doctor about the best way to feed your baby if you are taking this medicine.
Entresto can cause serious harm or death to an unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is not recommended while taking Entresto.
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How to Read This spironolactone vs valsartan Comparison
spironolactone is classified in the Potassium-Sparing Diuretic / Aldosterone Antagonist drug class, while valsartan sits within the Angiotensin II Receptor Blocker (ARB) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, spironolactone has 40,587 submissions while valsartan has 25,723. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these drugs can cause the body to hold onto potassium, which may lead to high potassium levels in the blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between spironolactone and valsartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.