oxycodone vs pregabalin
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Side-by-side comparison of oxycodone and pregabalin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
OxyContin, Roxicodone
Lyrica
Oxycodone is a strong pain medicine. It is used to treat severe pain that is not helped by other treatments.
Pregabalin (Lyrica) is a medicine that can help manage nerve pain, fibromyalgia, and partial-onset seizures. It works by calming overactive nerves in your body.
Oxycodone is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use it when other pain treatments are not enough. Talk to your doctor about other options if possible.
This medicine is used to treat nerve pain caused by diabetes, shingles, or spinal cord injury. It can also help with fibromyalgia, a condition that causes widespread pain. Pregabalin can also be used with other medicines to treat partial-onset seizures in adults and children as young as 1 month old.
Oxycodone works by changing how your brain and nervous system respond to pain. It attaches to certain receptors in the brain. This helps to block pain signals and reduce pain.
Pregabalin works by binding to certain areas in your brain and spinal cord. This action helps to reduce the release of chemicals that send pain signals. By reducing these signals, pregabalin can help to lessen pain and control seizures.
- • Feeling sick to your stomach
- • Constipation
- • Throwing up
- • Headache
- • Itching
- • Dizziness
- • Sleepiness
- • Dry mouth
- • Swelling
- • Blurred vision
- Drug Dependence 27,480
- Pain 26,409
- Death 19,598
- Overdose 19,081
- Toxicity To Various Agents 16,253
- Pain 25,902
- Fatigue 15,112
- Dizziness 14,524
- Nausea 14,053
- Headache 12,683
Oxycodone can cause serious, life-threatening risks: * Addiction, abuse, and misuse can lead to overdose and death. Your doctor will check your risk before prescribing and during treatment. * It can cause very slow or stopped breathing, especially when you start taking it or after a dose increase. * If a child accidentally takes even one dose, it can cause a fatal overdose. * Taking it with benzodiazepines (like Xanax) or other depressants (like alcohol) can cause sleepiness, slowed breathing, coma, and death. * Using oxycodone for a long time during pregnancy can cause withdrawal symptoms in the newborn. * Taking oxycodone with certain other medicines can cause dangerous side effects.
Pregabalin can cause swelling of the throat, head, and neck, which can be life-threatening. Get emergency help right away if this happens. This medicine can also increase the risk of suicidal thoughts or behavior. Watch for any changes in your mood or behavior. Pregabalin may cause dizziness and sleepiness, so be careful driving or operating machinery. Do not stop taking pregabalin suddenly, as this can cause increased seizures or other side effects.
Using oxycodone for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Talk to your doctor about the risks if you are pregnant or plan to become pregnant. Oxycodone is not recommended during labor, as it can cause breathing problems in the newborn.
Taking pregabalin during pregnancy may slightly increase the risk of birth defects. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of taking this medicine. Breastfeeding while taking pregabalin is not recommended.
Also Compare, Nearby Drugs
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How to Read This oxycodone vs pregabalin Comparison
oxycodone is classified in the Opioid Analgesic drug class, while pregabalin sits within the Anticonvulsant / Nerve Pain Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, oxycodone has 108,821 submissions while pregabalin has 82,274. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both medications slow down brain activity, which can cause dangerous levels of sleepiness and slow your breathing.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for oxycodone or pregabalin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.