olanzapine vs tetrabenazine
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Side-by-side comparison of olanzapine and tetrabenazine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by concomitant use of tetrabenazine and dopamine antagonists or antipsychotics (e.g., chlorpromazine, haloperidol, olanzapine, risperidone, thioridazine, ziprasidone) [see Warnings and Precautions ( 5.4 , 5.5 , 5.6 )] .
Zyprexa
Xenazine
Olanzapine is a medicine used to treat certain mental disorders. It helps to balance chemicals in the brain to improve mood and behavior.
Tetrabenazine is a medicine used to treat chorea (uncontrollable movements) caused by Huntington's disease. It helps to reduce these movements.
Olanzapine is used to treat schizophrenia in adults and teens (13-17). It also treats manic or mixed episodes of bipolar I disorder in adults and teens (13-17). In adults, it can be used with other medicines to treat bipolar depression.
Tetrabenazine is used to treat chorea, which are the involuntary, jerky movements that happen with Huntington's disease. Huntington's disease is a brain disorder that affects movement, behavior, and thinking. This medicine can help control the movements caused by this condition.
Olanzapine is an atypical antipsychotic. It works by affecting the levels of certain chemicals in your brain. These chemicals include dopamine and serotonin, which can help improve mood, thinking, and behavior.
Tetrabenazine works by affecting a substance in the brain that moves other chemicals. It lowers the amount of certain chemicals, like dopamine, in the brain. This helps to control the involuntary movements (chorea) caused by Huntington's disease.
- • Dizziness
- • Weight gain
- • Increased appetite
- • Dry mouth
- • Constipation
- • Feeling sleepy or drowsy
- • Feeling tired
- • Trouble sleeping
- • Feeling depressed
- • Feeling restless
- Weight Increased 6,722
- Diabetes Mellitus 5,388
- Drug Interaction 4,048
- Toxicity To Various Agents 3,966
- Somnolence 3,839
- Death 1,216
- Depression 474
- Somnolence 451
- Fatigue 360
- Fall 314
Olanzapine can increase the risk of death in older adults with dementia-related psychosis. Olanzapine is not approved to treat this condition. When using olanzapine with fluoxetine, read the Symbyax label for more warnings.
Tetrabenazine can increase the risk of depression and suicidal thoughts in people with Huntington's disease. If you have thoughts of harming yourself, tell your doctor right away. You should not take this medicine if you are actively suicidal or have untreated depression.
If you take olanzapine during the third trimester of pregnancy, your baby may have withdrawal symptoms after birth. There is a pregnancy registry to monitor outcomes in women who take atypical antipsychotics during pregnancy. Talk to your doctor.
This medicine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This olanzapine vs tetrabenazine Comparison
olanzapine is classified in the Atypical Antipsychotic drug class, while tetrabenazine sits within the VMAT2 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, olanzapine has 23,963 submissions while tetrabenazine has 2,815. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs lower dopamine activity in the brain, which can cause stiff muscles, tremors, or a dangerous fever.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for olanzapine or tetrabenazine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.