naproxen vs propranolol
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Side-by-side comparison of naproxen and propranolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: • NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Aleve, Naprosyn
Inderal
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It helps reduce pain, swelling, and stiffness.
Propranolol is a medicine that can help with high blood pressure, chest pain, and other conditions. It works by blocking the effects of certain natural chemicals in your body, like adrenaline, that affect the heart and blood vessels.
Naproxen is used to relieve pain and inflammation. You can use it for arthritis, including rheumatoid arthritis and osteoarthritis. It also treats ankylosing spondylitis and juvenile idiopathic arthritis. Naproxen can help with tendonitis, bursitis, gout, menstrual cramps, and general pain.
Propranolol tablets can treat high blood pressure. It can be used alone or with other medicines. Propranolol can also help with chest pain (angina), control fast heart rate with atrial fibrillation, improve survival after a heart attack, prevent migraine headaches, and reduce tremors. It can also help with symptoms of some tumors.
Naproxen works by reducing substances in the body that cause pain and inflammation. It blocks the production of prostaglandins. These substances contribute to the symptoms of pain, swelling, and fever.
Propranolol is a beta-blocker. It works by blocking the effects of adrenaline on your heart and blood vessels. This helps to slow down your heart rate and lower your blood pressure.
- • Heartburn
- • Abdominal pain
- • Nausea
- • Constipation
- • Diarrhea
- • Tiredness
- • Dizziness
- • Nausea
- • Vomiting
- • Diarrhea
- Pain 8,756
- Fatigue 7,339
- Arthralgia 7,243
- Nausea 7,062
- Headache 5,716
- Nausea 4,279
- Headache 3,785
- Fatigue 3,752
- Diarrhoea 3,119
- Dizziness 3,102
Naproxen may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take naproxen if you are having heart bypass surgery. Naproxen can also increase your risk of serious stomach and intestine problems, including bleeding, ulcers, and holes, which can be fatal. These problems can occur without warning. Elderly people are at higher risk.
Propranolol is contraindicated in people with cardiogenic shock, very slow heart rate, asthma, or those who are allergic to it.
Using naproxen after 20 weeks of pregnancy can cause kidney problems in the unborn baby, leading to low amniotic fluid. Avoid using naproxen at 30 weeks of pregnancy or later because it can cause the baby's heart to close too early. Talk to your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are pregnant or plan to become pregnant. Propranolol may affect your baby. Talk to your doctor about the risks and benefits of taking propranolol during pregnancy or while breastfeeding.
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How to Read This naproxen vs propranolol Comparison
naproxen is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while propranolol sits within the Non-Selective Beta-Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, naproxen has 36,116 submissions while propranolol has 18,037. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to naproxen can make blood pressure medications like propranolol less effective at lowering your blood pressure.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for naproxen or propranolol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.