Two medicines, side by side
Fluticasone vs prednisolone
Fluticasone and prednisolone are both labeled for allergies, asthma and eczema (atopic dermatitis). Drugs@FDA records approvals of fluticasone since 1990 and of prednisolone since 1955. Pharmacies paid $0.243 per gram (Fluticasone prop 0.05% cream) and $4.72 per mL (Prednisolone ac 1% eye drop) (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. Prednisolone's other strengths are brand-only: $30.66 per mL (Pred mild 0.12% eye drops).
Check it at the source: the fluticasone FDA label on DailyMed (effective December 19, 2024); the prednisolone FDA label on DailyMed (effective June 25, 2026).
Highlights of the fluticasone record
Fluticasone (Flonase) · label of December 19, 2024
Used for
From the label: indicationsTemporarily relieves these symptoms of hay fever or other upper respiratory allergies: • nasal congestion • itchy nose • runny nose • itchy, watery eyes • sneezing
On the market
- Earliest approval on file
- December 14, 1990
- Generic labelers
- 71 labelers
- Pharmacy cost
- $0.243 per gram
Supply and safety
- Shortage
- No current entry
- Recalls
- 5
Highlights of the prednisolone record
Prednisolone (Pred) · label of June 25, 2026
Used for
From the label: indicationsPrednisolone Sodium Phosphate Oral Solution is indicated in the following conditions: 1. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in adult and pediatric populations with: seasonal or perennial allergic rhinitis; asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions. 2. […]
On the market
- Earliest approval on file
- May 22, 1955
- Generic labelers
- 25 labelers
- Pharmacy cost
- $4.72 per mL
Supply and safety
- Shortage
- No current entry
- Recalls
- 9
Source: FDA drug labels via openFDA (Fluticasone label of December 19, 2024, Prednisolone label of June 25, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do fluticasone and prednisolone differ on the record?
Both are in FDA's class corticosteroids.
Generics: fluticasone since 2004; prednisolone since 1971 (Drugs@FDA).
| Fluticasone | Prednisolone | |
|---|---|---|
| Labeled for | Allergies, Asthma, Eczema (atopic dermatitis) | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Pharmacologic class | Corticosteroid | Corticosteroid |
| How it works (label) | n/a | n/a |
| Half-life (label) | n/a | Prednisolone is 70-90% protein-bound in the plasma and it is eliminated from the plasma with a half-life of 2 to 4 hours. |
| Earliest approval on file (Drugs@FDA) | December 14, 1990 | May 22, 1955 |
| First generic approved | May 14, 2004 | November 24, 1971 |
| Generic labelers (NDC) | 71 labelers | 25 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.243 per gram (Fluticasone prop 0.05% cream) | $4.72 per mL (Prednisolone ac 1% eye drop) |
| 12-month price change | -0.1% | +4% |
| Boxed warning | No | No |
| Shortage now | No current entry | No current entry |
| Recalls recorded | 5 | 9 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 139,949 | 191,407 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to fluticasone
- every medicine labeled for the same conditions