mirabegron vs solifenacin
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Side-by-side comparison of mirabegron and solifenacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug interaction studies were conducted in adult patients to investigate the effect of coadministered drugs on the pharmacokinetics of mirabegron and the effect of mirabegron on the pharmacokinetics of coadministered drugs (e.g., ketoconazole, rifampin, solifenacin succinate, tamsulosin, and oral contraceptives) [see Clinical Pharmacology ( 12.3 )] .
Myrbetriq
Vesicare
Mirabegron is a medicine that helps control an overactive bladder. It relaxes the bladder muscle, allowing it to hold more urine.
Solifenacin (Vesicare) is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
Mirabegron treats overactive bladder (OAB) in adults. OAB can cause you to feel a frequent and urgent need to urinate. It can also lead to accidental urine leakage (urge urinary incontinence).
This medicine treats overactive bladder in adults. It helps with symptoms like needing to urinate urgently, frequent urination, and leaking urine. It works to reduce these urges and help you control your bladder.
Mirabegron is a beta-3 adrenergic agonist. It works by relaxing the bladder muscle. This helps increase the bladder's capacity to store urine and reduces the urge to go.
Solifenacin blocks certain receptors in the bladder called muscarinic receptors. By blocking these receptors, the bladder muscle relaxes. This helps to reduce the urge to urinate frequently and reduces leakage.
- • High blood pressure
- • Common cold symptoms (nasopharyngitis)
- • Urinary tract infection
- • Headache
- • Dry mouth
- • Constipation
- • Urinary tract infection
- • Blurred vision
- Fatigue 2,215
- Headache 2,162
- Dizziness 2,093
- Fall 1,892
- Diarrhoea 1,861
- Dry mouth 1,616
- Constipation 1,613
- Tiredness 1,275
- Fall 1,226
- Dizziness 1,032
Mirabegron can raise your blood pressure. Your doctor should check your blood pressure regularly, especially if you have high blood pressure. Mirabegron is not recommended if you have severe, uncontrolled high blood pressure (180/110 mm Hg or higher). Use caution if you have bladder outlet obstruction or are taking other medicines for overactive bladder, as it can increase the risk of urinary retention. Angioedema (swelling of the face, lips, tongue, or throat) has been reported.
This medicine may cause swelling of the face, lips, tongue, or throat. If this happens, stop taking solifenacin and get medical help right away. This medicine is not recommended if you have a bladder problem that makes it hard to empty your bladder. It is also not recommended if you have slow movement in your stomach or intestines. This medicine may cause sleepiness, so be careful driving or operating heavy machinery until you know how it affects you.
It is not known if mirabegron can harm an unborn baby. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if solifenacin can harm your unborn baby. It is also not known if solifenacin passes into breast milk.
Also Compare, Nearby Drugs
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How to Read This mirabegron vs solifenacin Comparison
mirabegron is classified in the Beta-3 Agonist (Overactive Bladder) drug class, while solifenacin sits within the Anticholinergic (Overactive Bladder) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, mirabegron has 10,223 submissions while solifenacin has 6,762. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking these two bladder medicines together can slightly change how your body absorbs or handles each drug.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for mirabegron or solifenacin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.