methotrexate vs oxaprozin
Side-by-side comparison of methotrexate and oxaprozin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction) because NSAID administration may result in increased plasma levels of methotrexate, especially in patients receiving high doses of methotrexate. Intervention: During concomitant use of COXANTO and methotrexate, monitor patients for methotrexate toxicity.
Recommendation: Your doctor should monitor you closely for signs of methotrexate toxicity while you are taking both medications.
Trexall, Otrexup
Daypro
Methotrexate is a drug that can treat certain cancers, rheumatoid arthritis, psoriasis, and other conditions. It works by slowing the growth of cells in the body.
Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID). It helps to reduce pain and swelling.
Methotrexate can treat acute lymphoblastic leukemia, a type of cancer, in adults and children. It also treats mycosis fungoides, a skin lymphoma, in adults. Additionally, it treats relapsed or refractory non-Hodgkin lymphoma in adults. For non-cancer conditions, it treats rheumatoid arthritis in adults, polyarticular juvenile idiopathic arthritis (pJIA) in children, and severe psoriasis in adults.
This medicine can help with the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. These conditions can cause pain, swelling, and stiffness in your joints. Oxaprozin can help you feel better by reducing these symptoms.
Methotrexate blocks an enzyme called dihydrofolate reductase. This enzyme is needed for cells to grow and multiply. By blocking this enzyme, methotrexate slows down the growth of cells, especially cancer cells and cells that cause inflammation in arthritis and psoriasis.
Oxaprozin works by reducing substances in the body that cause pain and swelling. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain.
- • Mouth sores
- • Nausea
- • Abdominal pain
- • Changes in liver tests
- • Constipation
- • Diarrhea
- • Upset stomach
- • Nausea
- • Rash
- Rheumatoid arthritis 38,053
- Joint pain 36,283
- Pain 35,412
- Tiredness 29,061
- Feeling sick to your stomach 24,011
- Allergic reaction to the drug 386
- Pain 151
- Feeling sick to your stomach 134
- Headache 104
- Joint pain 103
Methotrexate can cause serious harm to an unborn baby, including death. If you are pregnant, you should not take this medicine for non-cancer conditions. If you are taking it for cancer, talk to your doctor about the risks. This medicine can also cause severe allergic reactions and other serious side effects that can be life-threatening. Contact your doctor immediately if you experience any signs of infection, lung problems, or kidney problems.
NSAIDs like oxaprozin can increase your risk of heart problems like heart attack and stroke. This risk can happen early in treatment and may increase with longer use. You should not take this medicine if you are having heart bypass surgery. NSAIDs also increase the risk of stomach and intestine problems like bleeding and ulcers, which can be fatal. Older adults and people with a history of stomach ulcers are at higher risk.
Methotrexate can cause birth defects or fetal death if taken during pregnancy for non-cancer conditions. If you are pregnant or plan to become pregnant, talk to your doctor. Do not breastfeed while taking methotrexate, as it can pass into breast milk and harm your baby.
Taking oxaprozin after 20 weeks of pregnancy may harm your baby. Avoid taking this medicine after 30 weeks of pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This methotrexate vs oxaprozin Comparison
methotrexate is classified in the Disease-Modifying Antirheumatic Drug (DMARD) drug class, while oxaprozin sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, methotrexate has 162,820 submissions while oxaprozin has 878. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to oxaprozin can cause methotrexate to build up in your blood to dangerous levels by making it harder for your body to clear the drug. this increases the risk of serious side effects like low blood cell counts or kidney problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between methotrexate and oxaprozin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.