metformin/empagliflozin vs phenytoin
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Side-by-side comparison of metformin/empagliflozin and phenytoin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.
Synjardy
Dilantin
Synjardy is a drug that combines empagliflozin and metformin. It helps lower blood sugar in people with type 2 diabetes, along with diet and exercise.
Phenytoin injection is used to treat certain types of seizures. It can also prevent seizures during or after neurosurgery.
Synjardy is used to treat type 2 diabetes in adults and children 10 years and older. It helps control blood sugar levels when used with diet and exercise. Empagliflozin, one of the drugs in Synjardy, can also lower the risk of heart-related death in adults with heart disease. It can also lower the risk of heart failure and kidney problems in adults with heart failure or chronic kidney disease.
This medicine treats generalized tonic-clonic status epilepticus, a type of prolonged seizure. It also helps prevent and treat seizures that may happen during or after brain surgery. Sometimes, it can be used for a short time instead of the oral form of phenytoin when you cannot take the medicine by mouth.
Synjardy contains two medicines that work in different ways. Empagliflozin helps your kidneys remove sugar from your blood through urine. Metformin lowers the amount of sugar your liver makes and helps your body use insulin better.
Phenytoin works by slowing down the signals in the brain that cause seizures. It stabilizes nerve cell membranes, reducing excessive electrical activity. This helps to prevent seizures from starting or spreading.
- • Urinary tract infections
- • Yeast infections of the vagina
- • Diarrhea
- • Nausea
- • Vomiting
No common side effects listed.
- Feeling sick to your stomach 21,946
- Loose or watery stools 21,887
- High blood sugar 18,329
- Feeling tired 17,252
- Sudden damage to the kidneys 16,440
- Drug Interaction 1,547
- Seizure 1,382
- Toxicity To Various Agents 1,353
- Convulsion 1,262
- Status Epilepticus 791
Metformin can cause a serious side effect called lactic acidosis. This is a buildup of lactic acid in your blood. It can be life-threatening. Get medical help right away if you have symptoms like feeling very weak, muscle pain, trouble breathing, stomach pain, dizziness, or a slow or irregular heartbeat.
This medicine can cause serious heart problems if given too quickly. The injection rate should not be faster than 50 mg per minute for adults, and 1 to 3 mg/kg/min (or 50 mg per minute, whichever is slower) for children. Your heart will be monitored closely during and after the injection.
Synjardy may harm your unborn baby, especially during the second and third trimesters. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking Synjardy.
Taking phenytoin during pregnancy may increase the risk of birth defects. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of this medicine.
How to Read This metformin/empagliflozin vs phenytoin Comparison
metformin/empagliflozin is classified in the Biguanide / SGLT2 Combination drug class, while phenytoin sits within the Anticonvulsant (Hydantoin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metformin/empagliflozin has 95,854 submissions while phenytoin has 6,335. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to phenytoin can interfere with how your body controls blood sugar, which may make your diabetes medicine less effective at lowering your glucose.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for metformin/empagliflozin or phenytoin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.