ketoconazole vs tamsulosin
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of ketoconazole and tamsulosin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS • Tamsulosin hydrochloride capsules 0.4 mg should not be used with strong inhibitors of CYP3A4 (e.g., ketoconazole). Concomitant treatment with ketoconazole (a strong inhibitor of CYP3A4) resulted in an increase in the C max and AUC of tamsulosin by a factor of 2.2 and 2.8, respectively [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3)]. Since CYP2D6 PMs cannot be readily identified and the potential for significant increase in tamsulosin exposure exists when tamsulosin hydrochloride capsules 0.4 mg is coadministered with strong CYP3A4 inhibitors in...
Nizoral
Flomax
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Tamsulosin (Flomax) helps to improve urination in men with enlarged prostate glands. It relaxes the muscles in the prostate and bladder, making it easier to urinate.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
This medicine treats the symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). BPH can cause problems with urination, like difficulty starting or stopping the flow of urine. Tamsulosin helps to relieve these symptoms.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Tamsulosin blocks alpha-1 adrenoceptors in the prostate and bladder. These receptors control muscle tightness. By blocking them, tamsulosin relaxes the muscles, which improves urine flow.
No common side effects listed.
- • Headache
- • Dizziness
- • Runny nose
- • Infection
- • Abnormal ejaculation
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Fatigue 1,417
- Dyspnoea 1,332
- Dizziness 1,131
- Diarrhoea 1,121
- Headache 883
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Tamsulosin can cause a sudden drop in blood pressure when you stand up, leading to dizziness or fainting. Avoid situations where you could get hurt if you faint. Tell your eye doctor if you are planning to have cataract or glaucoma surgery, as tamsulosin can cause complications during the procedure. You should be screened for prostate cancer before starting tamsulosin and regularly after.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
This medicine is only for men. It is not meant to be used by women. There is no information about the safety of tamsulosin during pregnancy or breastfeeding because it is not used in women.
Also Compare, Nearby Drugs
Compare ketoconazole with
Compare tamsulosin with
How to Read This ketoconazole vs tamsulosin Comparison
ketoconazole is classified in the Azole Antifungal drug class, while tamsulosin sits within the Alpha-1 Adrenergic Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while tamsulosin has 5,884. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzyme that breaks down tamsulosin, which can cause tamsulosin to build up to high levels in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or tamsulosin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.