ketoconazole vs solifenacin
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Side-by-side comparison of ketoconazole and solifenacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Concomitant use of ketoconazole, a strong CYP3A4 inhibitor, significantly increased the exposure of solifenacin [ see Clinical Pharmacology ( 12.3 ) ].
Nizoral
Vesicare
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Solifenacin (Vesicare) is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
This medicine treats overactive bladder in adults. It helps with symptoms like needing to urinate urgently, frequent urination, and leaking urine. It works to reduce these urges and help you control your bladder.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Solifenacin blocks certain receptors in the bladder called muscarinic receptors. By blocking these receptors, the bladder muscle relaxes. This helps to reduce the urge to urinate frequently and reduces leakage.
No common side effects listed.
- • Dry mouth
- • Constipation
- • Urinary tract infection
- • Blurred vision
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Dry mouth 1,616
- Constipation 1,613
- Tiredness 1,275
- Fall 1,226
- Dizziness 1,032
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
This medicine may cause swelling of the face, lips, tongue, or throat. If this happens, stop taking solifenacin and get medical help right away. This medicine is not recommended if you have a bladder problem that makes it hard to empty your bladder. It is also not recommended if you have slow movement in your stomach or intestines. This medicine may cause sleepiness, so be careful driving or operating heavy machinery until you know how it affects you.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if solifenacin can harm your unborn baby. It is also not known if solifenacin passes into breast milk.
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How to Read This ketoconazole vs solifenacin Comparison
ketoconazole is classified in the Azole Antifungal drug class, while solifenacin sits within the Anticholinergic (Overactive Bladder) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while solifenacin has 6,762. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole stops the body from breaking down solifenacin, which leads to higher levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or solifenacin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.