ketoconazole vs rabeprazole
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Side-by-side comparison of ketoconazole and rabeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole) Clinical Impact: Rabeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
Nizoral
Aciphex
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Rabeprazole (Aciphex) is a medicine that reduces the amount of acid your stomach makes. It belongs to a class of drugs called proton pump inhibitors (PPIs).
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
This medicine can treat several conditions caused by too much stomach acid. It can heal damage to your esophagus from acid reflux (GERD). It also treats heartburn, stomach ulcers, and conditions like Zollinger-Ellison syndrome where the body makes too much acid. Rabeprazole can also be used with antibiotics to get rid of a bacteria called H. pylori that can cause ulcers.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Rabeprazole works by blocking the enzyme in your stomach that produces acid. This helps to lower the amount of acid in your stomach. Lowering stomach acid helps to heal damage and relieve symptoms.
No common side effects listed.
- • Pain
- • Sore throat
- • Gas
- • Infection
- • Constipation
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Nausea 1,541
- Diarrhoea 1,319
- Pain 1,314
- Headache 1,284
- Dyspnoea 1,276
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Taking PPIs like rabeprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. This medicine may also increase your risk of bone fractures, especially if you take it for a long time or at high doses. Long-term use may also cause low vitamin B12 or magnesium levels. Contact your doctor right away if you experience signs of hypersensitivity.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
It is not known if rabeprazole is safe to use during pregnancy. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
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How to Read This ketoconazole vs rabeprazole Comparison
ketoconazole is classified in the Azole Antifungal drug class, while rabeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while rabeprazole has 6,734. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole needs stomach acid to be absorbed into your body, but rabeprazole reduces the amount of acid in your stomach.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or rabeprazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.