hydrochlorothiazide/triamterene vs lisinopril
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Side-by-side comparison of hydrochlorothiazide/triamterene and lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close...
Dyazide, Maxzide
Prinivil, Zestril
This medicine combines lisinopril and hydrochlorothiazide to lower high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
No summary available.
This medicine is used to treat high blood pressure. High blood pressure can lead to serious problems like stroke and heart attack if it is not treated. Lowering your blood pressure can help prevent these problems. You may need more than one medicine to control your blood pressure.
Information not available.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. This combination helps to lower blood pressure.
Information not available.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Lightheadedness when standing up
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- General pain 7,665
- Difficulty breathing 7,584
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
This medicine can harm your unborn baby. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not take this medicine if you have ever had a severe allergic reaction (angioedema) to an ACE inhibitor or if you cannot urinate.
No specific warnings noted.
This medicine can cause harm or death to an unborn baby. Do not take this medicine if you are pregnant. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
No pregnancy information available.
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How to Read This hydrochlorothiazide/triamterene vs lisinopril Comparison
hydrochlorothiazide/triamterene is classified in the Thiazide / Potassium-Sparing Diuretic Combination drug class, while lisinopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/triamterene has 43,279 submissions while lisinopril has 81,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking these two types of blood pressure medicines together can cause your blood pressure to drop too low, especially when you first start. this can make you feel very dizzy or lightheaded.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide/triamterene or lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.