griseofulvin vs warfarin
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Side-by-side comparison of griseofulvin and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Griseofulvin decreases the activity of warfarin-type anticoagulants, so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after griseofulvin therapy.
Grifulvin V
Coumadin, Jantoven
Griseofulvin is an antifungal medicine. It treats fungal infections of the skin, hair, and nails.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
This medicine treats fungal infections called dermatophyte infections. These infections can affect your skin (tinea corporis, tinea cruris, tinea barbae), feet (tinea pedis), scalp (tinea capitis), or nails (tinea unguium). Make sure a lab test confirms you have a fungal infection before you start taking this medicine. This medicine will not work for bacterial or yeast infections.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Griseofulvin stops fungi from growing and multiplying. It binds to a protein in the fungi. This disrupts the fungi's cell structure and prevents it from spreading.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Headache
- • Nausea
- • Vomiting
- • Diarrhea
- • Fatigue
- • Bleeding from any tissue or organ
- Headache 15
- Pyrexia 11
- Rash 11
- Diarrhoea 10
- Drug Hypersensitivity 10
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
Griseofulvin can cause liver problems. If you have liver failure or a history of sensitivity to griseofulvin, you should not take this medicine. Do not take this medicine if you have porphyria. Griseofulvin can harm an unborn baby, so do not take it if you are pregnant or could become pregnant.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Do not take this medicine if you are pregnant. It can cause harm to your unborn baby. Talk to your doctor about birth control options if you are a woman who could become pregnant.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
How to Read This griseofulvin vs warfarin Comparison
griseofulvin is classified in the Antifungal drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, griseofulvin has 57 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to griseofulvin makes warfarin less effective by helping the body get rid of it faster.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for griseofulvin or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.