furosemide vs indomethacin
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Side-by-side comparison of furosemide and indomethacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.
Lasix
Indocin
Furosemide is a water pill (diuretic). It helps your body get rid of extra water and salt.
Indomethacin is a drug that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
This medicine treats swelling (edema) from heart failure, liver problems, or kidney disease. It can also treat high blood pressure. Furosemide is helpful when you need a stronger diuretic.
Indomethacin treats moderate to severe rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It can also help with acute painful shoulder (bursitis or tendinitis) and gouty arthritis. This medicine reduces pain and swelling in your joints.
Furosemide works in your kidneys. It helps your kidneys remove more salt and water from your blood. This lowers the amount of fluid in your body and lowers blood pressure.
Indomethacin works by blocking substances in the body that cause pain and inflammation. These substances are called prostaglandins. By blocking them, indomethacin helps to reduce swelling, pain, and stiffness.
- • Dizziness
- • Headache
- • Blurred vision
- • Nausea
- • Vomiting
- • Headache
- • Dizziness
- • Upset stomach
- • Nausea
- Dyspnoea 29,104
- Fatigue 20,393
- Diarrhoea 19,937
- Nausea 18,692
- Acute Kidney Injury 18,530
- Fatigue 1,102
- Arthralgia 1,002
- Headache 990
- Pain 921
- Nausea 907
Furosemide can cause you to lose too much fluid and electrolytes. This can lead to dehydration, low blood pressure, and kidney problems. Your doctor should check your blood regularly while you are taking this medicine.
Indomethacin may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may occur early in treatment and may increase with longer use. You should not take this medicine before or after heart bypass surgery (CABG). Indomethacin can also increase your risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. Elderly patients and those with a history of ulcers or GI bleeding are at higher risk.
Tell your doctor if you are pregnant or plan to become pregnant. Furosemide may not be safe during pregnancy. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Using indomethacin during the later stages of pregnancy may harm your unborn baby. Limit use between 20 and 30 weeks of pregnancy, and avoid use after 30 weeks. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This furosemide vs indomethacin Comparison
furosemide is classified in the Loop Diuretic drug class, while indomethacin sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, furosemide has 106,656 submissions while indomethacin has 4,922. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to indomethacin blocks natural chemicals that help the water pill remove salt and lower blood pressure.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for furosemide or indomethacin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.