Two medicines, side by side
Fluticasone vs mometasone
Fluticasone and mometasone are both labeled for asthma and allergies. Drugs@FDA records approvals of fluticasone since 1990 and of mometasone since 1987. Pharmacies paid $0.243 per gram (Fluticasone prop 0.05% cream) and $0.354 per gram (Mometasone furoate 0.1% cream) (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like.
Check it at the source: the fluticasone FDA label on DailyMed (effective December 19, 2024); the mometasone FDA label on DailyMed (effective August 19, 2026).
Highlights of the fluticasone record
Fluticasone (Flonase) · label of December 19, 2024
Used for
From the label: indicationsTemporarily relieves these symptoms of hay fever or other upper respiratory allergies: • nasal congestion • itchy nose • runny nose • itchy, watery eyes • sneezing
On the market
- Earliest approval on file
- December 14, 1990
- Generic labelers
- 71 labelers
- Pharmacy cost
- $0.243 per gram
Supply and safety
- Shortage
- No current entry
- Recalls
- 5
Highlights of the mometasone record
Mometasone (Allergy) · label of August 19, 2026
Used for
From the label: indicationstemporarily relieves these symptoms of hay fever or other upper respiratory allergies: • nasal congestion • runny nose • sneezing • itchy nose
On the market
- Earliest approval on file
- April 30, 1987
- Generic labelers
- 16 labelers
- Pharmacy cost
- $0.354 per gram
Supply and safety
- Shortage
- No current entry
- Recalls
- 8
Source: FDA drug labels via openFDA (Fluticasone label of December 19, 2024, Mometasone label of August 19, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do fluticasone and mometasone differ on the record?
Both are in FDA's class corticosteroids.
Generics: fluticasone since 2004; mometasone since 2002 (Drugs@FDA).
| Fluticasone | Mometasone | |
|---|---|---|
| Labeled for | Allergies, Asthma, Eczema (atopic dermatitis) | Allergies, Asthma |
| Pharmacologic class | Corticosteroid | Corticosteroid |
| How it works (label) | n/a | n/a |
| Half-life (label) | n/a | n/a |
| Earliest approval on file (Drugs@FDA) | December 14, 1990 | April 30, 1987 |
| First generic approved | May 14, 2004 | March 18, 2002 |
| Generic labelers (NDC) | 71 labelers | 16 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.243 per gram (Fluticasone prop 0.05% cream) | $0.354 per gram (Mometasone furoate 0.1% cream) |
| 12-month price change | -0.1% | -3% |
| Boxed warning | No | No |
| Shortage now | No current entry | No current entry |
| Recalls recorded | 5 | 8 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 139,949 | 41,531 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to fluticasone
- every medicine labeled for the same conditions