fluticasone/umeclidinium/vilanterol vs ketoconazole
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Side-by-side comparison of fluticasone/umeclidinium/vilanterol and ketoconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol. Caution should be exercised when considering the coadministration of TRELEGY ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.9 ), Clinical Pharmacology ( 12.3 )] .
Trelegy Ellipta
Nizoral
Trelegy Ellipta is a medicine that contains three drugs in one inhaler. It helps people with COPD and asthma breathe easier.
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better. It is also used to treat asthma in adults aged 18 and older. This medicine is not for sudden breathing problems.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Trelegy Ellipta contains three medicines that work in different ways. Fluticasone reduces swelling in the lungs. Umeclidinium and vilanterol relax the muscles around your airways, making it easier to breathe.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
- • Upper respiratory infection
- • Pneumonia
- • Bronchitis
- • Oral thrush (Candida)
- • Headache
No common side effects listed.
No adverse event reports.
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
LABA medicines like vilanterol can raise the risk of asthma-related problems. Do not use Trelegy Ellipta for sudden, severe COPD or asthma symptoms. Rinse your mouth after use to prevent thrush. Trelegy Ellipta may increase your risk of pneumonia. It can also weaken your immune system and raise your risk of infections. It may cause problems with your heart, blood pressure, blood sugar, or bones. Long-term use may lead to glaucoma or cataracts. Tell your doctor if your glaucoma or urinary retention gets worse.
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Not enough information exists to determine if Trelegy Ellipta is safe during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
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How to Read This fluticasone/umeclidinium/vilanterol vs ketoconazole Comparison
fluticasone/umeclidinium/vilanterol is classified in the Triple Therapy (ICS/LAMA/LABA) drug class, while ketoconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluticasone/umeclidinium/vilanterol has 0 submissions while ketoconazole has 4,227. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzyme that clears the inhaler's ingredients from your system, causing the drug levels to rise.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluticasone/umeclidinium/vilanterol or ketoconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.