famciclovir vs probenecid

According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.

Side-by-side comparison of famciclovir and probenecid. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

7 DRUG INTERACTIONS Probenecid: May increase penciclovir levels. Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.

Drug Class
famciclovir Antiviral (Nucleoside Analog)
probenecid Uricosuric Agent
Type
famciclovir Prescription
probenecid Prescription
Summary
famciclovir

Famciclovir is an antiviral medicine. It helps to treat infections caused by certain viruses.

probenecid

No summary available.

What It Treats
famciclovir

This medicine treats herpes infections. It can treat cold sores, genital herpes, and shingles. It can also prevent genital herpes outbreaks. This medicine may not work for everyone, including first-time genital herpes, eye shingles, or certain immunocompromised patients.

probenecid

Information not available.

How It Works
famciclovir

Famciclovir stops the virus from multiplying. It does this by blocking a key enzyme the virus needs to make copies of itself. This helps your body fight off the infection.

probenecid

Information not available.

Common Side Effects
famciclovir
  • Headache
  • Nausea
probenecid
  • Diarrhea
  • Nausea
  • Yeast infection of the vagina
  • Headache
  • Vomiting
FAERS Reports
famciclovir
  • Fatigue 185
  • Diarrhoea 179
  • Nausea 145
  • Headache 135
  • Pain 118
probenecid
  • Diarrhoea 76
  • Dyspnoea 52
  • Adenovirus Infection 47
  • Asthenia 47
  • Fatigue 46
Serious Warnings
famciclovir

If you have kidney problems, make sure your doctor knows. Taking too much famciclovir when you have kidney problems can damage your kidneys.

probenecid

No specific warnings noted.

Pregnancy
famciclovir

Tell your doctor if you are pregnant or plan to become pregnant. Untreated herpes during pregnancy can harm the baby. It is not known if famciclovir passes into breast milk.

probenecid

No pregnancy information available.

Also Compare, Nearby Drugs

How to Read This famciclovir vs probenecid Comparison

famciclovir is classified in the Antiviral (Nucleoside Analog) drug class, while probenecid sits within the Uricosuric Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, famciclovir has 762 submissions while probenecid has 268. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to probenecid stops the kidneys from clearing the other medicine out of your system as quickly as usual.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for famciclovir or probenecid.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.