eplerenone vs hydrochlorothiazide/lisinopril
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Side-by-side comparison of eplerenone and hydrochlorothiazide/lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Inspra
Zestoretic
Eplerenone (Inspra) helps you live longer if you have heart failure after a heart attack. It also lowers blood pressure if you have high blood pressure.
Zestoretic is a drug that combines lisinopril and hydrochlorothiazide. It is used to treat high blood pressure.
Eplerenone is used to help people with heart failure who have had a heart attack live longer. It is also used to treat high blood pressure in adults. Lowering blood pressure helps reduce the risk of strokes and heart attacks.
Zestoretic is used to treat high blood pressure. Lowering blood pressure reduces the risk of heart problems and strokes. Controlling high blood pressure should also include managing cholesterol, diabetes, and quitting smoking. Many people need more than one medicine to control their blood pressure.
Eplerenone blocks a hormone called aldosterone in your body. Aldosterone can cause your body to hold onto too much salt and water, which can raise blood pressure and worsen heart failure. By blocking aldosterone, eplerenone helps lower blood pressure and reduce strain on the heart.
Zestoretic contains two medicines. Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
- • High potassium levels in your blood
- • Increased creatinine levels
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- Dyspnoea 1,083
- Cardiac Failure 939
- Acute Kidney Injury 905
- Hypotension 859
- Fatigue 659
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
Eplerenone can cause high potassium levels in your blood, which can be dangerous. Your doctor will check your potassium levels before you start taking eplerenone and regularly while you are taking it. People with kidney problems, diabetes, or who take certain other medicines are at higher risk.
This drug can cause serious harm or death to an unborn baby. Stop taking Zestoretic as soon as you find out you are pregnant.
It is not known if eplerenone can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if eplerenone passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking eplerenone.
Do not take Zestoretic if you are pregnant. It can harm your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
How to Read This eplerenone vs hydrochlorothiazide/lisinopril Comparison
eplerenone is classified in the Aldosterone Antagonist drug class, while hydrochlorothiazide/lisinopril sits within the Thiazide Diuretic / ACE Inhibitor Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, eplerenone has 4,445 submissions while hydrochlorothiazide/lisinopril has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medicines both cause your body to keep potassium instead of flushing it out. taking them together can lead to a dangerous increase in blood potassium levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for eplerenone or hydrochlorothiazide/lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.