efavirenz/emtricitabine/tenofovir vs posaconazole
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Side-by-side comparison of efavirenz/emtricitabine/tenofovir and posaconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Posaconazole ↓ posaconazole* Avoid concomitant use unless the benefit outweighs the risks.
Noxafil
Efavirenz is a drug used to treat HIV-1 infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTI).
Posaconazole is an antifungal medicine. It helps prevent certain fungal infections in people with weakened immune systems.
Efavirenz is used to treat HIV-1, the virus that causes AIDS. It helps to lower the amount of virus in your body. This medicine must be used with other HIV medicines.
Posaconazole prevents Aspergillus and Candida infections. You may need this medicine if you have a high risk of getting these infections. This often includes people who had a stem cell transplant or have certain blood cancers and are on chemotherapy.
Efavirenz blocks an enzyme called reverse transcriptase. HIV needs this enzyme to make copies of itself. By blocking it, efavirenz helps to slow down the spread of HIV in your body.
Posaconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. This helps your body fight off the infection.
- • Rash
- • Dizziness
- • Nausea
- • Headache
- • Fatigue
- • Diarrhea
- • Nausea
- • Fever
- • Vomiting
- • Headache
- Virologic Failure 952
- Drug Interaction 748
- Drug Resistance 735
- Viral Mutation Identified 674
- Pathogen Resistance 623
- Febrile Neutropenia 1,017
- Drug Interaction 930
- Death 928
- Pyrexia 850
- Neutropenia 705
Efavirenz can cause serious side effects, including psychiatric problems like depression or suicidal thoughts. Tell your doctor right away if you have any of these symptoms. Efavirenz can also harm your liver. Your doctor should check your liver function before and during treatment. Do not take efavirenz by itself.
Posaconazole can interact with many other medicines. It can cause heart rhythm problems (QT prolongation). It can also cause liver problems. Tell your doctor about all the medicines you take.
Efavirenz can harm your unborn baby, especially during the first 3 months of pregnancy. Talk to your doctor about using birth control while taking this medicine. Breastfeeding is not recommended while taking efavirenz.
Posaconazole may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if posaconazole passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This efavirenz/emtricitabine/tenofovir vs posaconazole Comparison
efavirenz/emtricitabine/tenofovir is classified in the NNRTI / NRTI Combination drug class, while posaconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, efavirenz/emtricitabine/tenofovir has 3,732 submissions while posaconazole has 4,430. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to efavirenz causes the body to break down posaconazole more quickly, which lowers the amount of medicine available to fight infections.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for efavirenz/emtricitabine/tenofovir or posaconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.