dutasteride vs warfarin
Side-by-side comparison of dutasteride and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7.2 Warfarin Dutasteride Concomitant administration of dutasteride 0.5 mg/day for 3 weeks with warfarin does not alter the steady-state pharmacokinetics of the S- or R-warfarin isomers or alter the effect of warfarin on prothrombin time [see Clinical Pharmacology ( 12.3 ) ] . Tamsulosin A definitive drug-drug interaction trial between tamsulosin hydrochloride and warfarin was not conducted. Caution should be exercised with concomitant administration of warfarin and tamsulosin-containing products, including dutasteride and tamsulosin hydrochloride capsules [see Warnings and Precautions (...
Recommendation: Use caution when taking these together and follow your doctor's advice for any extra blood tests.
Avodart
Coumadin, Jantoven
Dutasteride and tamsulosin hydrochloride capsules contain two medicines to treat enlarged prostate in men. They help improve symptoms like frequent urination.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men. It helps with symptoms like needing to urinate often, especially at night. It is for men who have an enlarged prostate causing these problems. This medicine is not approved to prevent prostate cancer.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Dutasteride lowers a hormone called dihydrotestosterone (DHT) that causes the prostate to grow. Tamsulosin relaxes the muscles in the prostate and bladder. This combination helps urine flow more easily.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Problems with ejaculation
- • Impotence (trouble getting or keeping an erection)
- • Decreased sex drive
- • Dizziness
- • Breast enlargement or tenderness
- • Bleeding from any tissue or organ
- Difficulty breathing 1,233
- Tiredness 1,142
- Feeling lightheaded or unsteady 986
- Weakness 933
- Loose stools 897
- INR increased 10,275
- Shortness of breath 8,408
- Interaction with another medicine 6,289
- Tiredness 6,141
- Feeling sick to your stomach 5,921
This medicine can cause dizziness or fainting, so be careful to avoid falls or injuries. Do not take this medicine with other alpha-blockers, as this can lower your blood pressure too much. This medicine can affect PSA levels, which are used to screen for prostate cancer. Tell your doctor you are taking this medicine before any PSA tests. This medicine may increase the risk of high-grade prostate cancer. Pregnant women should not handle this medicine.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
This medicine is not for use in women. It can cause birth defects in a male fetus if a pregnant woman is exposed to it. Pregnant women or women who may become pregnant should not handle these capsules.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This dutasteride vs warfarin Comparison
dutasteride is classified in the 5-Alpha Reductase Inhibitor drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dutasteride has 5,191 submissions while warfarin has 37,034. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to there is not enough research to know exactly how these drugs interact, but they might change how your blood-thinning medicine works.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dutasteride and warfarin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.