doxepin vs imipramine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of doxepin and imipramine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Sinequan, Silenor
Tofranil
Doxepin is a medicine that can help you stay asleep. It belongs to a class of drugs called tricyclic antidepressants.
Imipramine (Tofranil) is a medicine used to treat depression and bedwetting in children. It helps improve mood and reduce bedwetting episodes.
Doxepin is used to treat insomnia, which means you have trouble staying asleep. It can help you sleep better if you have problems with waking up during the night. This medicine has been tested for up to 3 months.
This medicine can help relieve the symptoms of depression. It may work better for some types of depression than others. Imipramine can also be used to help reduce bedwetting in children 6 years and older, but only after a doctor has ruled out other possible causes.
Doxepin works by affecting certain natural chemicals in the brain that help regulate sleep. It helps to keep you asleep throughout the night. It is a low dose formulation of a tricyclic antidepressant.
Imipramine is a tricyclic antidepressant. It works by increasing the levels of certain natural chemicals in the brain that help regulate mood. For bedwetting, it's thought to affect bladder control.
- • Feeling sleepy or drowsy
- • Feeling sick to your stomach
- • Upper respiratory tract infection (like a cold)
- • Dry mouth
- • Blurred vision
- • Constipation
- • Drowsiness
- • Dizziness
- Toxicity To Various Agents 801
- Completed Suicide 613
- Fatigue 599
- Nausea 557
- Pain 527
- Dizziness 35
- Fatigue 30
- Hypertension 29
- Anxiety 28
- Depression 28
After taking doxepin, some people have done things like driving a car while not fully awake. You might not remember doing it. This can be dangerous, so tell your doctor right away if this happens. Doxepin may also worsen depression or cause suicidal thoughts. Tell your doctor if you notice any new or worsening symptoms of depression.
Antidepressants may increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your doctor will monitor you closely for worsening depression, suicidal thoughts, or unusual changes in behavior. Families and caregivers should also watch for these changes.
Taking doxepin late in pregnancy may cause problems for the newborn baby, like trouble breathing or feeding. Breastfeeding is not recommended while taking this medicine.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. This medicine may not be safe for you or your baby. Talk to your doctor about the risks and benefits.
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How to Read This doxepin vs imipramine Comparison
doxepin is classified in the Tricyclic Antidepressant (TCA) drug class, while imipramine sits within the Tricyclic Antidepressant (TCA) class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, doxepin has 3,097 submissions while imipramine has 150. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for doxepin or imipramine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.