diltiazem vs simvastatin
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Side-by-side comparison of diltiazem and simvastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Cardizem, Tiazac
Zocor
Diltiazem is a medicine that helps lower high blood pressure and prevent chest pain. It belongs to a class of drugs called calcium channel blockers.
No summary available.
Diltiazem is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. Diltiazem also helps manage chronic stable angina (chest pain) and angina caused by spasms in the heart's blood vessels.
Information not available.
Diltiazem works by relaxing blood vessels, which lowers blood pressure. It also reduces the heart's workload, which can prevent chest pain. This medicine blocks calcium from entering heart and blood vessel cells.
Information not available.
- • Swelling in your ankles or feet
- • Headache
- • Dizziness
- • Slow heart rate
- • Constipation
- • Headache
- • Upper respiratory tract infection
- • Muscle pain
- • Diarrhea
- Dyspnoea 3,202
- Fatigue 2,638
- Nausea 2,372
- Pain 2,365
- Dizziness 2,091
- Fatigue 13,574
- Nausea 12,945
- Dyspnoea 12,431
- Diarrhoea 11,813
- Dizziness 10,971
Diltiazem can interact with other heart medications. Tell your doctor if you take beta-blockers or digoxin. Using diltiazem with these drugs can cause heart problems. Your doctor may need to adjust your dosages.
No specific warnings noted.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if diltiazem will harm your unborn baby. Diltiazem passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
No pregnancy information available.
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How to Read This diltiazem vs simvastatin Comparison
diltiazem is classified in the Calcium Channel Blocker drug class, while simvastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diltiazem has 12,668 submissions while simvastatin has 61,734. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to diltiazem blocks the enzymes that break down simvastatin, causing the drug to stay in your body longer. this can lead to a higher risk of muscle pain or damage.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diltiazem or simvastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.