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digoxin vs rosiglitazone

Side-by-side comparison of digoxin and rosiglitazone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

[See Clinical Pharmacology (12.4).] 7.2 Cationic Drugs Although drug interactions for metformin with cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of AVANDAMET and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.

Recommendation: Your healthcare provider should monitor you closely and may need to adjust the dose of your medications.

Drug Class
digoxin Cardiac Glycoside
rosiglitazone Thiazolidinedione
Type
digoxin Prescription
rosiglitazone Prescription
Summary
digoxin

Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.

rosiglitazone

No summary available.

What It Treats
digoxin

Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.

rosiglitazone

Information not available.

How It Works
digoxin

Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.

rosiglitazone

Information not available.

Common Side Effects
digoxin
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Headache
rosiglitazone
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Upset stomach
FAERS Reports
digoxin
  • Shortness of breath 6,062
  • Feeling sick to your stomach 4,747
  • Feeling lightheaded or unsteady 4,442
  • Feeling very tired 4,174
  • Irregular heartbeat 3,972
rosiglitazone

No adverse event reports.

Serious Warnings
digoxin

Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.

rosiglitazone

No specific warnings noted.

Pregnancy
digoxin

It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.

rosiglitazone

No pregnancy information available.

Also Compare, Nearby Drugs

Compare rosiglitazone with

How to Read This digoxin vs rosiglitazone Comparison

digoxin is classified in the Cardiac Glycoside drug class, while rosiglitazone sits within the Thiazolidinedione class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,397 submissions while rosiglitazone has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs are processed by the same part of the kidney, which might interfere with how quickly the body gets rid of them.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between digoxin and rosiglitazone - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.