digoxin vs hydrochlorothiazide/triamterene
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of digoxin and hydrochlorothiazide/triamterene. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant adverse interactions. No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Lanoxin
Dyazide, Maxzide
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
This medicine combines lisinopril and hydrochlorothiazide to lower high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
This medicine is used to treat high blood pressure. High blood pressure can lead to serious problems like stroke and heart attack if it is not treated. Lowering your blood pressure can help prevent these problems. You may need more than one medicine to control your blood pressure.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. This combination helps to lower blood pressure.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Lightheadedness when standing up
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- General pain 7,665
- Difficulty breathing 7,584
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
This medicine can harm your unborn baby. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not take this medicine if you have ever had a severe allergic reaction (angioedema) to an ACE inhibitor or if you cannot urinate.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
This medicine can cause harm or death to an unborn baby. Do not take this medicine if you are pregnant. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
How to Read This digoxin vs hydrochlorothiazide/triamterene Comparison
digoxin is classified in the Cardiac Glycoside drug class, while hydrochlorothiazide/triamterene sits within the Thiazide / Potassium-Sparing Diuretic Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while hydrochlorothiazide/triamterene has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs do not significantly change how the other is processed by your body when used together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or hydrochlorothiazide/triamterene.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.