digoxin vs flecainide
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Side-by-side comparison of digoxin and flecainide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
During administration of multiple oral doses of flecainide acetate to healthy subjects stabilized on a maintenance dose of digoxin , a 13% to 19% increase in plasma digoxin levels occurred at six hours postdose.
Lanoxin
Tambocor
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Flecainide is a medicine used to prevent irregular heartbeats. It helps your heart beat normally.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
This medicine can prevent fast heart rates in the upper chambers of the heart. This includes supraventricular tachycardia and atrial fibrillation/flutter. Flecainide can also prevent life-threatening fast heartbeats in the lower chambers (ventricles). It is usually started in the hospital for these serious ventricular problems.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Flecainide works by slowing down electrical signals in the heart. This helps to stabilize your heart rhythm. It belongs to a class of drugs called Class IC antiarrhythmics.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Dizziness
- • Vision problems
- • Difficulty breathing
- • Headache
- • Nausea
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Irregular heartbeat in the upper chambers 337
- Feeling tired 276
- Difficulty breathing 270
- Feeling lightheaded 255
- Feeling sick to your stomach 244
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Flecainide can increase the risk of death or cardiac arrest in some patients who have had a heart attack. It is generally not recommended for people with less serious, but unpleasant, heart rhythm problems. Flecainide is also not recommended if you have chronic atrial fibrillation.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if flecainide can harm an unborn baby. Talk to your doctor about the risks and benefits of taking flecainide while breastfeeding.
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How to Read This digoxin vs flecainide Comparison
digoxin is classified in the Cardiac Glycoside drug class, while flecainide sits within the Class IC Antiarrhythmic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while flecainide has 1,382. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking flecainide can cause the amount of digoxin in your blood to rise slightly.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or flecainide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.