diflunisal vs furosemide
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Side-by-side comparison of diflunisal and furosemide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Diuretics Clinical studies, as well as postmarketing observations, have shown that diflunisal can reduce the natriuretic effect of furosemide and thiazides in some patients.
Dolobid
Lasix
Diflunisal is a medicine that can help with pain and swelling. It belongs to a class of drugs called NSAIDs.
Furosemide is a water pill (diuretic). It helps your body get rid of extra water and salt.
Diflunisal can help with mild to moderate pain. It can also treat the symptoms of osteoarthritis and rheumatoid arthritis. You should use the lowest dose that works for you, for the shortest time needed.
This medicine treats swelling (edema) from heart failure, liver problems, or kidney disease. It can also treat high blood pressure. Furosemide is helpful when you need a stronger diuretic.
Diflunisal reduces pain and swelling by blocking the production of certain chemicals in your body. These chemicals cause inflammation and pain. By blocking them, diflunisal helps to relieve your symptoms.
Furosemide works in your kidneys. It helps your kidneys remove more salt and water from your blood. This lowers the amount of fluid in your body and lowers blood pressure.
- • Nausea
- • Vomiting
- • Upset stomach
- • Stomach pain
- • Diarrhea
- • Dizziness
- • Headache
- • Blurred vision
- • Nausea
- • Vomiting
- Nausea 66
- Fatigue 57
- Pain 50
- Drug Hypersensitivity 47
- Headache 45
- Dyspnoea 29,104
- Fatigue 20,393
- Diarrhoea 19,937
- Nausea 18,692
- Acute Kidney Injury 18,530
NSAIDs like diflunisal can increase your risk of heart problems like heart attack and stroke, which can be deadly. This risk is higher if you take it for a long time. You should not take diflunisal if you are having heart bypass surgery. NSAIDs also raise your risk of serious stomach problems like bleeding and ulcers, which can also be deadly. Older adults are at higher risk for these stomach problems.
Furosemide can cause you to lose too much fluid and electrolytes. This can lead to dehydration, low blood pressure, and kidney problems. Your doctor should check your blood regularly while you are taking this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Taking diflunisal late in pregnancy may harm your baby. It is not known if diflunisal passes into breast milk, so talk to your doctor before breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Furosemide may not be safe during pregnancy. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
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How to Read This diflunisal vs furosemide Comparison
diflunisal is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while furosemide sits within the Loop Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diflunisal has 265 submissions while furosemide has 106,656. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to diflunisal can stop the water pill from helping the body get rid of extra salt. this makes the water pill less effective at reducing swelling or lowering blood pressure.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diflunisal or furosemide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.