dexmethylphenidate vs lisdexamfetamine
Side-by-side comparison of dexmethylphenidate and lisdexamfetamine Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Focalin, Focalin XR
Vyvanse
AZSTARYS is a stimulant medicine used to treat ADHD. It can help increase attention and decrease impulsiveness and hyperactivity.
Lisdexamfetamine (Vyvanse) is a stimulant medicine. It can help improve focus and reduce impulsive behavior.
AZSTARYS is used to treat Attention Deficit Hyperactivity Disorder (ADHD) in people 6 years and older. ADHD can make it hard to focus, pay attention, and control impulsive behaviors. This medicine can help manage these symptoms.
This medicine treats Attention Deficit Hyperactivity Disorder (ADHD) in adults and kids 6 years and older. It also treats moderate to severe binge eating disorder (BED) in adults. This medicine is not for weight loss.
AZSTARYS contains two ingredients that affect chemicals in the brain. These chemicals help improve focus and attention. One ingredient is released right away, and the other is released slowly over time.
Lisdexamfetamine affects chemicals in your brain. These chemicals help control hyperactivity and impulses. It can also help reduce binge eating.
- • Decreased appetite
- • Trouble sleeping
- • Feeling sick to your stomach
- • Stomach pain
- • Weight loss
- • Anorexia
- • Anxiety
- • Decreased appetite
- • Weight loss
- • Diarrhea
- The medicine is not working 740
- Feeling sick to your stomach 196
- Feeling worried or nervous 189
- Pain in your head 183
- Feeling very tired 169
- Taking too much medicine on purpose 1,068
- Purposely hurting yourself 1,009
- Medicine not working 904
- Problem getting the medicine 487
- Feeling tired 402
AZSTARYS has a high risk for abuse and addiction. Misusing it can lead to overdose and death. Your doctor will check your risk before and during treatment. Store it safely and don't give it to others.
This medicine has a high risk for abuse, misuse, and addiction. Misusing it can lead to overdose and death. Your doctor will check your risk before and during treatment. Store this medicine safely and do not share it with anyone.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if AZSTARYS will harm your unborn baby. There is a pregnancy registry to track outcomes in women who take ADHD medicines during pregnancy.
This medicine may harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Breastfeeding is not recommended while taking this medicine.
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How to Read This dexmethylphenidate vs lisdexamfetamine Comparison
dexmethylphenidate is classified in the CNS Stimulant drug class, while lisdexamfetamine sits within the CNS Stimulant class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dexmethylphenidate has 1,477 submissions while lisdexamfetamine has 3,870. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dexmethylphenidate and lisdexamfetamine — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.